Brand  (β version)

PDB ID: 1C2G

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Ligands
Code Name Style Show Link
BAH Bis(5-amidino-2-benzimidazolyl)methane ketone hydrate PoSSuM
CA Calcium ion PoSSuM
DMS Dimethyl sulfoxide PoSSuM
MG Magnesium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1C2G   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Release Data : 2000-07-26
Compound :
mol_id molecule chains
1 TRYPSIN A
ec: 3.4.21.4
other_details: COMPLEXED WITH BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANE KETONE HYDRATE
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
Authors : Katz, B.A., Luong, C.
Keywords : ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE/INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

Design of potent selective zinc-mediated serine protease inhibitors.

Katz, B.A.,Clark, J.M.,Finer-Moore, J.S.  et al.
(1998)  Nature  391 : 608 - 612

PubMed: 9468142
DOI: 10.1038/35422

Reaction

Chain : A
UniProt : P00760 (TRY1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. 3.4.21.4 -
-
Cofactor: Evidence: Note:
Ca(2+) - Binds 1 Ca(2+) ion per subunit.