Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CA Calcium ion
MG Magnesium ion
ZN Zinc ion
BAI (5-amidino-2-benzimidazolyl)(2-benzimidazolyl)methane
DMS Dimethyl sulfoxide
SO4 Sulfate ion
Code : 1C1R
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Release Data : 2000-07-26
Compound :
mol_id molecule chains
1 TRYPSIN A
ec: 3.4.21.4
other_details: COMPLEXED WITH (5-AMIDINO-2-BENZIMIDAZOLYL)(2-BENZIMIDAZOLYL)METHANE
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
Authors : Katz, B.A., Luong, C.
Keywords : ZN(II)-MEDIATED SERINE PROTEASE INHIBITORS, PH DEPENDENCE, ZN(II) AFFINITY STUCTURE-BASED DRUG DESIGN, SERINE PROTEASE SERINE PROTEASE/INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.37 Å )
Citation :

Design of potent selective zinc-mediated serine protease inhibitors.

Katz, B.A.,Clark, J.M.,Finer-Moore, J.S.  et al.
(1998)  Nature  391 : 608 - 612

PubMed: 9468142
DOI: 10.1038/35422

Chain : A
UniProt : P00760 (TRY1_BOVIN)
Reaction : Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.