PDB ID: 1C1B
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Structure summary
Code : | 1C1B PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | TRANSFERASE | ||||||||||||||||||||||||
Title : | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186 | ||||||||||||||||||||||||
Release Data : | 2000-07-21 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Hopkins, A.L., Ren, J., Tanaka, H., Baba, B., Okamato, M., Stuart, D.I., Stammers, D.K. | ||||||||||||||||||||||||
Keywords : | HIV-1 REVERSE TRANSCRIPTASE, AIDS, NON-NUCLEOSIDE INHIBITOR, DRUG DESIGN, TRANSFERASE | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.5 Å ) | ||||||||||||||||||||||||
Citation : |
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
Hopkins, A.L.,Ren, J.,Tanaka, H.
et al.
PubMed: 10579814 Crystallographic Analysis of the Binding Modes of Thiazoloisoindolinone Non-nucleoside Inhibitors to HIV-1 Reverse Transcriptase and Comparison with Modelling Studies
Ren, J.,Esnouf, R.M.,Hopkins, A.L.
et al.
DOI: 10.1021/jm990275t Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives
Ren, J.,Esnouf, R.M.,Hopkins, A.L.
et al.
DOI: 10.1021/bi981309m 3'-azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes
Ren, J.,Esnouf, R.M.,Hopkins, A.L.
et al.
Continuous and discontinuous changes in the unit cell of HIV-1 reverse transcriptase crystals on dehydration
Esnouf, R.M.,Ren, J.,Garman, E.
et al.
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this non-nucleoside inhibitor
Esnouf, R.M.,Ren, J.,Hopkins, A.L.
et al.
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors
Hopkins, A.L.,Ren, J.,Esnouf, R.M.
et al.
DOI: 10.1021/jm960056x The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design
Ren, J.,Esnouf, R.M.,Hopkins, A.L.
et al.
High Resolution Structures of HIV-1 RT From Four RT-inhibitor Complexes
Ren, J.,Esnouf, R.M.,Garman, E.
et al.
Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Non-nucleoside Inhibitors
Esnouf, R.M.,Ren, J.,Ross, C.K.
et al.
Crystals of HIV-1 Reverse Transcriptase Diffracting to 2.2 Angstrom Resolution
Stammers, D.K.,Somers, D.O.,Ross, C.K.
et al.
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Reaction
Chain : | B | ||||||||||||||||||||||||
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UniProt : | P04585 (POL_HV1H2) | ||||||||||||||||||||||||
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