Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
BSI 2-(biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
CA Calcium ion
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
ZN Zinc ion
Code : 1BZS
Header : HYDROLASE
Title : CRYSTAL STRUCTURE OF MMP8 COMPLEXED WITH HMR2909
Release Data : 2000-05-31
Compound :
mol_id molecule chains synonym
1 NEUTROPHIL COLLAGENASE A MMP-8
ec: 3.4.24.34
fragment: CATALYTIC DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
cell: NEUTROPHIL
expression_system_strain: BL21
expression_system_variant: BL21
expression_system_plasmid: PET
Authors : Schreuder, H., Brachvogel, V., Loenze, P.
Keywords : METALLO PROTEINASE, HYDROXAMATE, MATRIX DEGRADATION, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.7 Å )
Citation :

Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis.

Matter, H.,Schwab, W.,Barbier, D.  et al.
(1999)  J.Med.Chem.  42 : 1908 - 1920

PubMed: 10354399
DOI: 10.1021/jm980631s

Chain : A
UniProt : P22894 (MMP8_HUMAN)
Reaction : Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.