Brand  (β version)

PDB ID: 1BYU

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Ligands
Code Name Style Show Link
GDP Guanosine-5'-diphosphate PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1BYU   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : CANINE GDP-RAN
Release Data : 1998-12-02
Compound :
mol_id molecule chains synonym
1 PROTEIN (GTP-BINDING PROTEIN RAN) A,B TC4
fragment: ALL
Source :
mol_id organism_scientific organism_common expression_system
1 Canis lupus familiaris  (taxid:9615) Dog Escherichia coli BL21(DE3)  (taxid:469008)
strain: BL21(DE3)
expression_system_strain: BL21 (DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PET
Authors : Stewart, M., Kent, H.M., Mccoy, A.J.
Keywords : GTPASE, NUCLEAR TRANSPORT, TRANSPORT PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2).

Stewart, M.,Kent, H.M.,McCoy, A.J.
(1998)  J.Mol.Biol.  284 : 1517 - 1527

PubMed: 9878368
DOI: 10.1006/jmbi.1998.2204

Reaction

Chain : A, B
UniProt : P62825 (RAN_CANLF)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - UniProtKB:P62826
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:9878368
Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.