Brand  (β version)

PDB ID: 1BX6

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Ligands
Code Name Style Show Link
BA1 Balanol PoSSuM
Non-standard Residues
Code Name Show
SEP Phosphoserine
TPO Phosphothreonine
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 1BX6   PDBj   RCSB PDB   PDBe
Header : SERINE/THREONINE-PROTEIN KINASE
Title : CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
Release Data : 1999-04-27
Compound :
mol_id molecule chains synonym
1 CAMP-DEPENDENT PROTEIN KINASE A CAPK OR PKA
ec: 2.7.1.37
fragment: CATALYTIC DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli  (taxid:562)
Authors : Narayana, N., Xuong, N.-H., Ten Eyck, L.F., Taylor, S.S.
Keywords : SERINE/THREONINE-PROTEIN KINASE, BALANOL, CONFORMATIONAL CHANGES, INHIBITION, PROTEIN KINASE PKA, SERINE-THREONINE-PROTEIN KINASE complex
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase.

Narayana, N.,Diller, T.C.,Koide, K.  et al.
(1999)  Biochemistry  38 : 2367 - 2376

PubMed: 10029530
DOI: 10.1021/bi9820659

A Binary Complex of the Catalytic Subunit of Camp-Dependent Protein Kinase and Adenosine Further Defines Conformational Flexibility

Narayana, N.,Cox, S.,Xuong, N.H.  et al.
(1997)  Structure  5 : 921

Crystal Structure of a Polyhistidine-Tagged Recombinant Catalytic Subunit of Camp-Dependent Protein Kinase Complexed with the Peptide Inhibitor Pki(5-24) and Adenosine

Narayana, N.,Cox, S.,Shaltiel, S.  et al.
(1997)  Biochemistry  36 : 4438

Crystal Structure of the Catalytic Subunit of Camp-Dependent Protein Kinase Complexed with Mgatp and Peptide Inhibitor

Zheng, J.,Knighton, D.R.,Ten Eyck, L.F.  et al.
(1993)  Biochemistry  32 : 2154

Expression of the Catalytic Subunit of Camp-Dependent Protein Kinase in Escherichia Coli: Multiple Isozymes Reflect Different Phosphorylation States

Herberg, F.W.,Bell, S.M.,Taylor, S.S.
(1993)  Protein Eng.  6 : 771

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Knighton, D.R.,Zheng, J.H.,Ten Eyck, L.F.  et al.
(1991)  Science  253 : 407

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Knighton, D.R.,Zheng, J.H.,Ten Eyck, L.F.  et al.
(1991)  Science  253 : 414

Reaction

Chain : A
UniProt : P05132 (KAPCA_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.11 PubMed:10805756, PubMed:19223768
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.11 PubMed:10805756, PubMed:19223768
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