Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FE Fe (III) ion
NO Nitric oxide
ACV L-D-(a-aminoadipoyl)-L-cysteinyl-D-valine
Code : 1BLZ
Header : B-LACTAM ANTIBIOTIC
Title : ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACV-FE-NO COMPLEX)
Release Data : 1999-01-13
Compound :
mol_id molecule chains
1 ISOPENICILLIN N SYNTHASE A
Source :
mol_id organism_scientific expression_system
1 Emericella nidulans  (taxid:162425) Escherichia coli  (taxid:562)
gene: PCB C
expression_system_strain: NM554
expression_system_plasmid: PJB703
Authors : Roach, P.L., Clifton, I.J., Hensgens, C.M.H., Shibata, N., Schofield, C.J., Hajdu, J., Baldwin, J.E.
Keywords : B-LACTAM ANTIBIOTIC, OXYGENASE, PENICILLIN BIOSYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 1.45 Å )
Citation :

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.

Roach, P.L.,Clifton, I.J.,Hensgens, C.M.  et al.
(1997)  Nature  387 : 827 - 830

PubMed: 9194566
DOI: 10.1038/42990

Crystal Structure of Isopenicillin N Synthase is the First from a New Structural Family of Enzymes

Roach, P.L.,Clifton, I.J.,Fulop, V.  et al.
(1995)  Nature  375 : 700

Crystallization and Preliminary X-Ray Diffraction Studies on Recombinant Isopenicillin N Synthase from Aspergillus Nidulans

Roach, P.L.,Schofield, C.J.,Baldwin, J.E.  et al.
(1995)  Protein Sci.  4 : 1007

Chain : A
UniProt : P05326 (IPNS_EMENI)
Reaction : N-((5S)-5-amino-5-carboxypentanoyl)-L- cysteinyl-D-valine + O(2) = isopenicillin N + 2 H(2)O.