Brand  (β version)

PDB ID: 1BLZ

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Ligands
Code Name Style Show Link
ACV L-D-(a-aminoadipoyl)-L-cysteinyl-D-valine PoSSuM
FE Fe (III) ion PoSSuM
NO Nitric oxide PoSSuM
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Structure summary

Code : 1BLZ   PDBj   RCSB PDB   PDBe
Header : B-LACTAM ANTIBIOTIC
Title : ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACV-FE-NO COMPLEX)
Release Data : 1999-01-13
Compound :
mol_id molecule chains
1 ISOPENICILLIN N SYNTHASE A
Source :
mol_id organism_scientific expression_system
1 Emericella nidulans  (taxid:162425) Escherichia coli  (taxid:562)
gene: PCB C
expression_system_strain: NM554
expression_system_plasmid: PJB703
Authors : Roach, P.L., Clifton, I.J., Hensgens, C.M.H., Shibata, N., Schofield, C.J., Hajdu, J., Baldwin, J.E.
Keywords : B-LACTAM ANTIBIOTIC, OXYGENASE, PENICILLIN BIOSYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 1.45 Å )
Citation :

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.

Roach, P.L.,Clifton, I.J.,Hensgens, C.M.  et al.
(1997)  Nature  387 : 827 - 830

PubMed: 9194566
DOI: 10.1038/42990

Crystal Structure of Isopenicillin N Synthase is the First from a New Structural Family of Enzymes

Roach, P.L.,Clifton, I.J.,Fulop, V.  et al.
(1995)  Nature  375 : 700

Crystallization and Preliminary X-Ray Diffraction Studies on Recombinant Isopenicillin N Synthase from Aspergillus Nidulans

Roach, P.L.,Schofield, C.J.,Baldwin, J.E.  et al.
(1995)  Protein Sci.  4 : 1007

Reaction

Chain : A
UniProt : P05326 (IPNA_EMENI)
Reaction: EC: Evidence:
Physiological Direction:
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N 1.21.3.1 PubMed:11755401, PubMed:28703303, PubMed:3319778
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