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Ligands
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FOS [[N-(benzyloxycarbonyl)amino]methyl]phosphate
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Glycosylation
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Code : 1BLH   PDBj   RCSB PDB   PDBe
Header : HYDROLASE(BETA-LACTAMASE)
Title : STRUCTURE OF A PHOSPHONATE-INHIBITED BETA-LACTAMASE. AN ANALOG OF THE TETRAHEDRAL TRANSITION STATE(SLASH)INTERMEDIATE OF BETA-LACTAM HYDROLYSIS
Release Data : 1994-08-31
Compound :
mol_id molecule chains
1 BETA-LACTAMASE A
ec: 3.5.2.6
Source :
mol_id organism_scientific
1 Staphylococcus aureus  (taxid:1280)
Authors : Chen, C.C.H., Herzberg, O.
Keywords : HYDROLASE(BETA-LACTAMASE)
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Structure of a phosphonate-inhibited beta-lactamase. An analog of the tetrahedral transition state/intermediate of beta-lactam hydrolysis.

Chen, C.C.,Rahil, J.,Pratt, R.F.  et al.
(1993)  J.Mol.Biol.  234 : 165 - 178

PubMed: 8230196
DOI: 10.1006/jmbi.1993.1571

Inhibition of Beta-Lactamase by Clavulanate. Trapped Intermediates in Cryocrystallographic Studies

Chen, C.C.H.,Herzberg, O.
(1992)  J.Mol.Biol.  224 : 1103

Refined Crystal Structure of Beta-Lactamase from Staphylococcus Aureus Pc1 at 2.0 Angstroms Resolution

Herzberg, O.
(1991)  J.Mol.Biol.  217 : 701

Structural Basis for the Inactivation of the P54 Mutant of Beta-Lactamase from Staphylococcus Aureus Pc1

Herzberg, O.,Kapadia, G.,Blanco, B.  et al.
(1991)  Biochemistry  30 : 9504

Penicillin-Binding and Degrading Enzymes

Herzberg, O.,Moult, J.
(1991)  Curr.Opin.Struct.Biol.  1 : 946

Bacterial Resistance to Beta-Lactam Antibiotics. Crystal Structure of Beta-Lactamase from Staphylococcus Aureus Pc1 at 2.5 Angstroms Resolution

Herzberg, O.,Moult, J.
(1987)  Science  236 : 694

The Crystal Structure of Beta-Lactamase from Staphylococcus Aureus at 0.5Nm Resolution

Moult, J.,Sawyer, L.,Herzberg, O.  et al.
(1985)  Biochem.J.  225 : 167

Chain : A
UniProt : P00807 (BLAC_STAAU)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE- ProRule:PRU10101
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