Brand  (β version)

PDB ID: 1BLC

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Ligands
Code Name Style Show Link
CEM N-(1-carboxy-2-hydroxy-4-oxo-butyl)-N-(3-oxo-cispropenyl)amine PoSSuM
SO4 Sulfate ion PoSSuM
TEM N-(2-hydroxy-4-oxo-butyl)-N-(3-oxo-transpropenyl)amine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1BLC   PDBj   RCSB PDB   PDBe
Header : HYDROLASE(ACTING IN CYCLIC AMIDES)
Title : INHIBITION OF BETA-LACTAMASE BY CLAVULANATE: TRAPPED INTERMEDIATES IN CRYOCRYSTALLOGRAPHIC STUDIES
Release Data : 1994-01-31
Compound :
mol_id molecule chains
1 BETA-LACTAMASE A
ec: 3.5.2.6
Source :
mol_id organism_scientific
1 Staphylococcus aureus  (taxid:1280)
Authors : Chen, C.C.H., Herzberg, O.
Keywords : HYDROLASE(ACTING IN CYCLIC AMIDES)
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Inhibition of beta-lactamase by clavulanate. Trapped intermediates in cryocrystallographic studies.

Chen, C.C.,Herzberg, O.
(1992)  J.Mol.Biol.  224 : 1103 - 1113

PubMed: 1569569
DOI: 10.1016/0022-2836(92)90472-V

Structure of a Phosphonate-Inhibited Beta-Lactamase: An Analog of the Tetrahedral Transition State(Slash)Intermediate of Beta-Lactam Hydrolysis

Chen, C.C.H.,Rahil, J.,Pratt, R.F.  et al.
To be Published 

Refined Crystal Structure of Beta-Lactamase from Staphylococcus Aureus Pc1 at 2.0 Angstroms Resolution

Herzberg, O.
(1991)  J.Mol.Biol.  217 : 701

Structural Basis for the Inactivation of the P54 Mutant of Beta-Lactamase from Staphylococcus Aureus Pc1

Herzberg, O.,Kapadia, G.,Blanco, B.  et al.
(1991)  Biochemistry  30 : 9503

Penicillin-Binding and Degrading Enzymes

Herzberg, O.,Moult, J.
(1991)  Curr.Opin.Struct.Biol.  1 : 946

Bacterial Resistance to Beta-Lactam Antibiotics. Crystal Structure of Beta-Lactamase from Staphylococcus Aureus Pc1 at 2.5 Angstroms Resolution

Herzberg, O.,Moult, J.
(1987)  Science  236 : 694

The Crystal Structure of Beta-Lactamase from Staphylococcus Aureus at 0.5Nm Resolution

Moult, J.,Sawyer, L.,Herzberg, O.  et al.
(1985)  J.Biochem.(Tokyo)  225 : 167

Reaction

Chain : A
UniProt : P00807 (BLAC_STAAU)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE- ProRule:PRU10101
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