Brand  (β version)

PDB ID: 1BJI

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
DPC 5-acetylamino-4-amino-6-(phenethyl-propyl-carbamoyl)-5,6-dihydro-4h-pyran-2-carboxylic acid PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 1BJI   PDBj   RCSB PDB   PDBe
Header : NEURAMINIDASE
Title : THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH THE GLAXO 6-CARBOXAMIDE SIALIC ACID ANALOGUE GR217029
Release Data : 1998-06-03
Compound :
mol_id molecule chains synonym
1 NEURAMINIDASE A SIALIDASE
ec: 3.2.1.18
fragment: RESIDUES 82 - 468
other_details: INTEGRAL MEMBRANE PROTEIN, MEMBRANE BOUND STALK CLEAVED BY PRONASE, RELEASING FULLY ACTIVE HEAD WITH RESIDUES 82 - 468
Source :
mol_id organism_scientific
1 Influenza A virus  (taxid:11320)
strain: A/TERN/AUSTRALIA/G70C/75
other_details: DETERGENT RELEASED, PRONASE DIGESTED
Authors : Varghese, J.N.
Keywords : NEURAMINIDASE, INFLUENZA PROTEIN, INHIBITOR COMPLEX, 6-CARBOXAMIDE DERIVATIVE, SIALIC ACID ANALOGUE, GLAXO GR217029, HYDROLASE, GLYCOPROTEIN
Exp. method : X-RAY DIFFRACTION ( 2. Å )
Citation :

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.

Taylor, N.R.,Cleasby, A.,Singh, O.  et al.
(1998)  J.Med.Chem.  41 : 798 - 807

PubMed: 9526556
DOI: 10.1021/jm9703754

Reaction

Chain : A
UniProt : P03472 (NRAM_I75A5)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 3.2.1.18 HAMAP-Rule:MF_04071, PubMed:23429702
-
Cofactor: Evidence: Note:
Ca(2+) ECO:0000255 | HAMAP-Rule:MF_04071
ECO:0000269 | PubMed:23429702
ECO:0000269 | PubMed:7549872
ECO:0000269 | PubMed:8371267
ECO:0000269 | PubMed:9342319
Binds 1 Ca(2+) ion per subunit.