Brand  (β version)

PDB ID: 1BIQ

Hetero Atom Contents

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Code Name Style Show Link
FE Fe (III) ion PoSSuM
FE2 Fe (II) ion PoSSuM
HG Mercury (II) ion PoSSuM
OH Hydroxide ion PoSSuM

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Non-standard Residues
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MTY Meta-tyrosine
Glycosylation
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Structure summary

Code : 1BIQ   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN MUTANT E238A
Release Data : 1999-01-13
Compound :
mol_id molecule chains synonym
1 PROTEIN R2 OF RIBONUCLEOTIDE REDUCTASE A RNR R2
ec: 1.17.4.1
fragment: BETA CHAIN
mutation: Y122F, E238A
mol_id molecule chains synonym
2 PROTEIN R2 OF RIBONUCLEOTIDE REDUCTASE B RNR R2
ec: 1.17.4.1
fragment: BETA CHAIN
mutation: Y122F, E238A
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
strain: MC1009
expression_system_strain: MC1009
expression_system_plasmid: PGP1-2/PTB2
mol_id organism_scientific expression_system
2 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
strain: MC1009
expression_system_strain: MC1009
expression_system_plasmid: PGP1-2/PTB2
Authors : Logan, D.T., Demare, F., Persson, B.O., Slaby, A., Sjoberg, B.M., Nordlund, P.
Keywords : OXIDOREDUCTASE, DNA REPLICATION, IRON
Exp. method : X-RAY DIFFRACTION ( 2.05 Å )
Citation :

Crystal structures of two self-hydroxylating ribonucleotide reductase protein R2 mutants: structural basis for the oxygen-insertion step of hydroxylation reactions catalyzed by diiron proteins.

Logan, D.T.,deMare, F.,Persson, B.O.  et al.
(1998)  Biochemistry  37 : 10798 - 10807

PubMed: 9692970
DOI: 10.1021/bi9806403

Structure and Function of the Escherichia Coli Ribonucleotide Reductase Protein R2

Nordlund, P.,Eklund, H.
(1993)  J.Mol.Biol.  232 : 123

Reaction

Chain : B
UniProt : P69924 (RIR2_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]- disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]- dithiol 1.17.4.1 PROSITE-ProRule:PRU10014
-
Cofactor: Evidence: Note:
Fe cation - Binds 2 iron ions per subunit.