Het-PDB Navi2 (PDB: 1BIM)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
0QB	(2s)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-{(1s,2s)-1-(cyclohexylmethyl)-2-hydroxy-2-[(3r)-1,5,5-trimethyl-2-oxopyrrolidin-3-yl]ethyl}-N~4~-[2-(dimethylamino)-2-oxoethyl]-N~4~-[(1s)-1-phenylethyl]butanediamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1BIM

Code :

1BIM PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS

Release Data :

1996-01-29

Compound :

mol_id	molecule	chains	synonym
1	Renin	A,B	Angiotensinogenase
	ec: 3.4.23.15 other_details: GLYCOSYLATED

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Canis lupus familiaris (taxid:9615)
	gene: CMV IE-HUMAN PREPRORENIN CDNA, REN expression_system_common: Dog expression_system_strain: familiaris expression_system_plasmid: PMNC RETROVIRAL VECTOR expression_system_gene: CMV IE-HUMAN PREPRORENIN CDNA other_details: STABLY TRANSFERRED

Authors :

Tong, L.

Keywords :

ASPARTIC PROTEINASE, Aspartyl protease, Cleavage on pair of basic residues, Disease mutation, Disulfide bond, Glycoprotein, Hydrolase, Membrane, Protease, Secreted, Zymogen, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.8 Å )

Citation :

Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors.

Tong, L.,Pav, S.,Lamarre, D. et al.
(1995) J.Biol.Chem. 270 : 29520 - 29524

PubMed: 7493993
DOI: 10.1074/jbc.270.49.29520

Chain :

A, B

UniProt :

P00797 (RENI_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Cleavage of Leu-\|-Xaa bond in angiotensinogen to generate angiotensin I.	3.4.23.15	PubMed:12045255, PubMed:20927107
	-	PubMed:12045255, PubMed:20927107

PDB ID: 1BIM

Hetero Atom Contents

Structure summary

Reaction