Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
UMP 2'-deoxyuridine 5'-monophosphate
Modified Residues
Code Name Link
FMT Formic acid
Code : 1BID
Header : METHYLTRANSFERASE
Title : E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP
Release Data : 1998-07-01
Compound :
mol_id molecule chains synonym
1 THYMIDYLATE SYNTHASE A TS, THYMIDYLATE SYNTHETASE
ec: 2.1.1.45
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
cell_line: CHI-2913
gene: THYA
expression_system_cell_line: CHI-2913
expression_system_vector: BLUESCRIPT
expression_system_plasmid: PTHYA-WT
expression_system_gene: THYA
Authors : Stout, T.J., Sage, C.R., Stroud, R.M.
Keywords : TRANSFERASE (METHYLTRANSFERASE), SUBSTRATE MODULES, METHYLTRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

The additivity of substrate fragments in enzyme-ligand binding.

Stout, T.J.,Sage, C.R.,Stroud, R.M.
(1998)  Structure  6 : 839 - 848

PubMed: 9687366
DOI: 10.1016/S0969-2126(98)00086-0

Chain : A
UniProt : P0A884 (TYSY_ECOLI)
Reaction : 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.