Brand  (β version)

PDB ID: 1BG3

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
BGC Beta-D-glucopyranose PoSSuM
G6P 6-O-phosphono-alpha-D-glucopyranose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1BG3   PDBj   RCSB PDB   PDBe
Header : HEXOKINASE
Title : RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE
Release Data : 1999-06-08
Compound :
mol_id molecule chains synonym
1 HEXOKINASE A,B ATP-D-HEXOSE-6-PHOSPHOTRANSFERASE
ec: 2.7.1.1
other_details: BOTH MONOMERS HAVE TWO SMALL BREAKS AT KNOWN OR LIKELY TRYPSIN CLEAVAGE SITES. ALTHOUGH ENZYME IS ACTIVE AS A MONOMER, DIMERIZATION OCCURS AT HIGH PROTEIN CONCENTRATION, PARTICULARLY IN THE PRESENCE OF THE INHIBITOR G6P
Source :
mol_id organism_scientific organism_common
1 Rattus norvegicus  (taxid:10116) Norway rat
organ: BRAIN
tissue: BRAIN
Authors : Mulichak, A.M., Garavito, R.M.
Keywords : HEXOKINASE, PHOSPHOTRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

The structure of mammalian hexokinase-1.

Mulichak, A.M.,Wilson, J.E.,Padmanabhan, K.  et al.
(1998)  Nat.Struct.Biol.  5 : 555 - 560

PubMed: 9665168
DOI: 10.1038/811

Reaction

Chain : A, B
UniProt : P05708 (HXK1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+) 2.7.1.1 PubMed:13211595, PubMed:3579310, PubMed:5871820
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D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+) 2.7.1.1 PubMed:13211595, PubMed:5871820
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D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+) 2.7.1.1 PubMed:13211595, PubMed:5871820
left-to-right PubMed:5871820
D-mannose + ATP = D-mannose 6-phosphate + ADP + H(+) 2.7.1.1 PubMed:13211595
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D-glucosamine + ATP = D-glucosamine 6-phosphate + ADP + H(+) 2.7.1.1 UniProtKB:P19367
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