Brand  (β version)

PDB ID: 1BEU

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Ligands
Code Name Style Show Link
IPL Indole-3-propanol phosphate PoSSuM
K Potassium ion PoSSuM
PLS [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1BEU   PDBj   RCSB PDB   PDBe
Header : CARBON-OXYGEN LYASE
Title : TRP SYNTHASE (D60N-IPP-SER) WITH K+
Release Data : 1998-08-12
Compound :
mol_id molecule chains
1 TRYPTOPHAN SYNTHASE A
ec: 4.2.1.20
mutation: CHAIN A, D60N
other_details: LIGAND INDOLE-3-PROPANOL PHOSPHATE BOUND TO THE A-SUBUNIT AND L-SERINE BOUND TO THE B-SUBUNIT
mol_id molecule chains
2 TRYPTOPHAN SYNTHASE B
ec: 4.2.1.20
mutation: CHAIN A, D60N
other_details: LIGAND INDOLE-3-PROPANOL PHOSPHATE BOUND TO THE A-SUBUNIT AND L-SERINE BOUND TO THE B-SUBUNIT
Source :
mol_id organism_scientific expression_system
1 Salmonella typhimurium  (taxid:602) Escherichia coli  (taxid:562)
cell_line: CB149
gene: TRPA/TRPB
expression_system_cell_line: CB149
expression_system_plasmid: PSTB7
expression_system_gene: TRPA/TRPB
mol_id organism_scientific expression_system
2 Salmonella typhimurium  (taxid:602) Escherichia coli  (taxid:562)
cell_line: CB149
gene: TRPA/TRPB
expression_system_cell_line: CB149
expression_system_plasmid: PSTB7
expression_system_gene: TRPA/TRPB
Authors : Rhee, S., Mozzarelli, A., Miles, E.W., Davies, D.R.
Keywords : CARBON-OXYGEN LYASE, MUTATION D60N IN A-SUBUNIT, INDOLE-3-PROPANOL PHOSPHATE IN A-SUBUNIT, L-SERINE IN B-SUBUNIT
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60.

Rhee, S.,Miles, E.W.,Mozzarelli, A.  et al.
(1998)  Biochemistry  37 : 10653 - 10659

PubMed: 9692955
DOI: 10.1021/bi980779d

Reaction

Chain : A
UniProt : P00929 (TRPA_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan 4.2.1.20 HAMAP-Rule:MF_00131
-
Chain : B
UniProt : P0A2K1 (TRPB_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan 4.2.1.20 -
-