Het-PDB Navi2 (PDB: 1BCK)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
BMT	4-methyl-4-[(E)-2-butenyl]-4,N-methyl-threonine
DAL	D-alanine
MLE	N-methylleucine
MVA	N-methylvaline
SAR	Sarcosine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1BCK

Code :

1BCK PDBj RCSB PDB PDBe

Header :

ISOMERASE/IMMUNOSUPPRESSANT

Title :

HUMAN CYCLOPHILIN A COMPLEXED WITH 2-THR CYCLOSPORIN

Release Data :

1998-09-16

Compound :

mol_id	molecule	chains	synonym
1	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A	A	PPIASE, ROTAMASE, CYCLOPHILIN A
	ec: 5.2.1.8

mol_id	molecule	chains	synonym
2	CYCLOSPORIN C	C	CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:562)
	gene: CYCLOPHILIN expression_system_gene: CYCLOPHILIN

mol_id	organism_scientific
2	TOLYPOCLADIUM INFLATUM (taxid:29910)
	synthetic: yes

Authors :

Mikol, V., Kallen, J., Taylor, P., Walkinshaw, M.D.

Keywords :

ISOMERASE-IMMUNOSUPPRESSANT COMPLEX, CYCLOPHILIN-CYCLOSPORIN COMPLEX, CYCLOSPORIN C, IMMUNOSUPPRESSANT

Exp. method :

X-RAY DIFFRACTION ( 1.80 Å )

Citation :

X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Kallen, J.,Mikol, V.,Taylor, P. et al.
(1998) J.Mol.Biol. 283 : 435

Chain :

UniProt :

P62937 (PPIA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0)	5.2.1.8	PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563, PubMed:19207730, PubMed:26095851
	-

PDB ID: 1BCK