Brand  (β version)

PDB ID: 1B9S

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FDI 4-(N-acetylamino)-3-[N-(2-ethylbutanoylamino)]benzoic acid PoSSuM
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose PoSSuM
Non-standard Residues
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Structure summary

Code : 1B9S   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : NOVEL AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE MAKE SELECTIVE INTERACTIONS WITH CONSERVED RESIDUES AND WATER MOLECULES IN THE ACTIVE SITE
Release Data : 1999-02-26
Compound :
mol_id molecule chains synonym
1 PROTEIN (NEURAMINIDASE) A SIALIDASE
ec: 3.2.1.18
Source :
mol_id organism_scientific
1 Influenza B virus (B/Lee/40)  (taxid:107412)
strain: B/Lee/40
cellular_location: CELL MEMBRANE
Authors : Finley, J.B., Atigadda, V.R., Duarte, F., Zhao, J.J., Brouillette, W.J., Air, G.M., Luo, M.
Keywords : NEURAMINIDASE, SIALIDASE, INFLUENZA, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site.

Finley, J.B.,Atigadda, V.R.,Duarte, F.  et al.
(1999)  J.Mol.Biol.  293 : 1107 - 1119

PubMed: 10547289
DOI: 10.1006/jmbi.1999.3180

Reaction

Chain : A
UniProt : P03474 (NRAM_INBLE)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 3.2.1.18 HAMAP- Rule:MF_04071
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