Het-PDB Navi2 (PDB: 1B99)

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Ligands
Code	Name		Style	Show	Link
FUP	2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate				PoSSuM
POP	Pyrophosphate 2-				PoSSuM

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Download interaction data: 1B99

Code :

1B99 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

3'-FLUORO-URIDINE DIPHOSPHATE BINDING TO NUCLEOSIDE DIPHOSPHATE KINASE

Release Data :

1999-06-28

Compound :

mol_id	molecule	chains	synonym
1	PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE)	A,B,C,D,E,F	NDPK
	ec: 2.7.4.6 fragment: HEXAMER

Source :

mol_id	organism_scientific	expression_system
1	Dictyostelium discoideum (taxid:44689)	Escherichia coli (taxid:562)

Authors :

Janin, J., Xu, Y.

Keywords :

PHOSPHOTRANSFERASE, ANTIVIRAL AGENT, FLUOROURIDINE, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.7 Å )

Citation :

Catalytic mechanism of nucleoside diphosphate kinase investigated using nucleotide analogues, viscosity effects, and X-ray crystallography.

Gonin, P.,Xu, Y.,Milon, L. et al.
(1999) Biochemistry 38 : 7265 - 7272

PubMed: 10353838
DOI: 10.1021/bi982990v

Mechanism of Phosphate Transfer by Nucleoside Diphosphate Kinase: X-Ray Structures of the Phosphohistidine Intermediate of the Enzymes from Drosophila and Dictyostelium

Morera, S.,Chiadmi, M.,Lebras, G. et al.
(1995) Biochemistry 34 : 11062

Adenosine 5'-Diphosphate Binding and the Active Site of Nucleoside Diphosphate Kinase

Morera, S.,Lascu, I.,Dumas, C. et al.
(1994) Biochemistry 33 : 459

Chain :

A, B, C, D, E, F

UniProt :

P22887 (NDKC_DICDI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP	2.7.4.6	-
	-	-
a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP	2.7.4.6	-
	-	-

PDB ID: 1B99

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