Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CO Cobalt (II) ion
TN4 (1r,2s,3s,4r)-4-hydroxy-2-methoxy-4-methyl-3-[(2r,3r)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]cyclohexyl (chloroacetyl)carbamate
Code : 1B6A   PDBj   RCSB PDB   PDBe
Header : ANGIOGENESIS INHIBITOR
Title : HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470
Release Data : 2000-01-13
Compound :
mol_id molecule chains
1 METHIONINE AMINOPEPTIDASE A
ec: 3.4.11.18
other_details: TNP-470 COVALENTLY LINKED TO HIS 231 NE2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda MNPV  (taxid:10455)
cellular_location: CYTOPLASM
expression_system_cell_line: SF21
expression_system_vector: BACULOVIRUS PACSG2
Authors : Liu, S., Clardy, J.C.
Keywords : ANGIOGENESIS INHIBITOR, AMINOPEPTIDASE
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Structure of human methionine aminopeptidase-2 complexed with fumagillin.

Liu, S.,Widom, J.,Kemp, C.W.  et al.
(1998)  Science  282 : 1324 - 1327

PubMed: 9812898
DOI: 10.1126/science.282.5392.1324

Chain : A
UniProt : P50579 (MAP2_HUMAN)
Reaction : Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.