Brand  (β version)

PDB ID: 1B5T

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
HG Mercury (II) ion PoSSuM
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Structure summary

Code : 1B5T   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : ESCHERICHIA COLI METHYLENETETRAHYDROFOLATE REDUCTASE
Release Data : 1999-01-20
Compound :
mol_id molecule chains
1 PROTEIN (METHYLENETETRAHYDROFOLATE REDUCTASE) A,B,C
ec: 1.7.99.5
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: METF
Authors : Guenther, B.D., Sheppard, C.A., Tran, P., Rozen, R., Matthews, R.G., Ludwig, M.L.
Keywords : BETA ALPHA BARREL, REDUCTASE, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia.

Guenther, B.D.,Sheppard, C.A.,Tran, P.  et al.
(1999)  Nat.Struct.Biol.  6 : 359 - 365

PubMed: 10201405
DOI: 10.1038/7594

Reaction

Chain : A, B, C
UniProt : P00394 (METF_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10- methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH 1.5.1.54 PubMed:11371182, PubMed:19610625, PubMed:9922232, PubMed:14275142
right-to-left PubMed:14275142, PubMed:9922232