Brand  (β version)

PDB ID: 1B59

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Ligands
Code Name Style Show Link
CO Cobalt (II) ion PoSSuM
OVA 3,4-dihydroxy-2-methoxy-4-methyl-3-[2-methyl-3-(3-methyl-but-2-enyl) -oxiranyl]-cyclohexanone PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1B59   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : COMPLEX OF HUMAN METHIONINE AMINOPEPTIDASE-2 COMPLEXED WITH OVALICIN
Release Data : 2000-01-14
Compound :
mol_id molecule chains synonym
1 PROTEIN (METHIONINE AMINOPEPTIDASE) A METAP 2
ec: 3.4.11.18
other_details: OVALICIN COVALENTLY LINKED TO HIS 231 NE2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda MNPV  (taxid:10455)
cellular_location: CYTOPLASM
expression_system_strain: SF21
expression_system_cell_line: SF21
expression_system_vector_type: VIRUS
expression_system_vector: BACULOVIRUS
other_details: PROTEIN WAS EXPRESSED IN SF21 INSECT CELLS.. BACULOVIRUS PACSG2 VECTOR
Authors : Liu, S., Clardy, J.C.
Keywords : ANGIOGENESIS INHIBITOR, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Structure of human methionine aminopeptidase-2 complexed with fumagillin.

Liu, S.,Widom, J.,Kemp, C.W.  et al.
(1998)  Science  282 : 1324 - 1327

PubMed: 9812898
DOI: 10.1126/science.282.5392.1324

Reaction

Chain : A
UniProt : P50579 (MAP2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. 3.4.11.18 HAMAP-Rule:MF_03175, PubMed:20521764
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