Brand  (β version)

PDB ID: 1B4S

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Ligands
Code Name Style Show Link
ADP Adenosine-5'-diphosphate PoSSuM
MG Magnesium ion PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1B4S   PDBj   RCSB PDB   PDBe
Header : PHOSPHOTRANSFERASE
Title : STRUCTURE OF NUCLEOSIDE DIPHOSPHATE KINASE H122G MUTANT
Release Data : 1999-06-15
Compound :
mol_id molecule chains synonym
1 NUCLEOSIDE DIPHOSPHATE KINASE A,B,C NDPK
ec: 2.7.4.6
mutation: H122G
Source :
mol_id organism_scientific expression_system
1 Dictyostelium discoideum  (taxid:44689) Escherichia coli  (taxid:562)
Authors : Meyer, P., Janin, J.
Keywords : TRANSFERASE, KINASE, ATP-BINDING, PHOSPHOTRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Nucleophilic activation by positioning in phosphoryl transfer catalyzed by nucleoside diphosphate kinase.

Admiraal, S.J.,Schneider, B.,Meyer, P.  et al.
(1999)  Biochemistry  38 : 4701 - 4711

PubMed: 10200157
DOI: 10.1021/bi9827565

Mechanism of Phosphate Transfer by Nucleoside Diphosphate Kinase: X-Ray Structures of the Phosphohistidine Intermediate of the Enzymes from Drosophila and Dictyostelium

Morera, S.,Chiadmi, M.,Lebras, G.  et al.
(1995)  Biochemistry  34 : 11062

Adenosine 5'-Diphosphate Binding and the Active Site of Nucleoside Diphosphate Kinase

Morera, S.,Lascu, I.,Dumas, C.  et al.
(1994)  Biochemistry  33 : 459

Reaction

Chain : A, B, C
UniProt : P22887 (NDKC_DICDI)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP 2.7.4.6 -
-
a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP 2.7.4.6 -
-