Het-PDB Navi2 (PDB: 1B4E)

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Ligands
Code	Name	Link
GOL	Glycerol	PoSSuM
SHF	Laevulinic acid	PoSSuM
SO4	Sulfate ion	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Download interaction data: 1B4E

Code :

1B4E PDBj RCSB PDB PDBe

Header :

LYASE

Title :

X-ray structure of 5-aminolevulinic acid dehydratase complexed with the inhibitor levulinic acid

Release Data :

1999-12-17

Compound :

mol_id	molecule	chains	synonym
1	PROTEIN (5-AMINOLEVULINIC ACID DEHYDRATASE)	A	ALAD
	ec: 4.2.1.24

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	gene: HEM2

Authors :

Erskine, P.T., Cooper, J.B., Lewis, G., Spencer, P., Wood, S.P., Shoolingin-Jordan, P.M.

Keywords :

DEHYDRATASE, LYASE

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

X-ray structure of 5-aminolevulinic acid dehydratase from Escherichia coli complexed with the inhibitor levulinic acid at 2.0 A resolution.

Erskine, P.T.,Norton, E.,Cooper, J.B. et al.
(1999) Biochemistry 38 : 4266 - 4276

Chain :

UniProt :

P0ACB2 (HEM2_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)	4.2.1.24	PubMed:8439296
2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)	-	PubMed:8439296
Cofactor:	Evidence:	Note:
Zn(2+)	ECO:0000269 \| PubMed:10194344 ECO:0000269 \| PubMed:11444968 ECO:0000269 \| PubMed:11909869 ECO:0000269 \| PubMed:7592604 ECO:0000269 \| PubMed:8439296	Binds 1 zinc ion per monomer.

PDB ID: 1B4E