Het-PDB Navi2 (PDB: 1B4D)

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Ligands
Code	Name	Link
IMP	Inosinic acid	PoSSuM
PLP	Pyridoxal-5'-phosphate	PoSSuM
CRA	1-deoxy-1-methoxycarbamido-beta-D-gluco-2-heptulopyranosonamide	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1B4D

Code :

1B4D PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

AMIDOCARBAMATE INHIBITOR OF GLYCOGEN PHOSPHORYLASE

Release Data :

1998-12-23

Compound :

mol_id	molecule	chains
1	PROTEIN (GLYCOGEN PHOSPHORYLASE B)	A
	ec: 2.4.1.1

Source :

mol_id	organism_scientific	organism_common
1	Oryctolagus cuniculus (taxid:9986)	Rabbit
	tissue: MUSCLE

Authors :

Tsitsanou, K.E., Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Gregoriou, M., Watson, K.A., Johnson, L.N., Fleet, G.W.J.

Keywords :

GLYCOGEN PHOSPHORYLASE, INHIBITOR BINDING, AMIDOCARBAMATE, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.

Tsitsanou, K.E.,Oikonomakos, N.G.,Zographos, S.E. et al.
(1999) Protein Sci. 8 : 741 - 749

PubMed: 10211820

Stereospecific Synthesis of Spirohydantoins of Beta-Glucopyranose:Inhibitors of Glycogen Phosphorylase

Krulle, T.M.,De La Fuente, C.,Watson, K.A. et al.
(1997) Synlett : 211

N-Acetyl-Beta-D-Glucopyranosylamine:A Potent T-State Inhibitor of Glycogen Phosphorylase. A Comparison with Alpha-D-Glucose

Oikonomakos, N.G.,Kontou, M.,Zographos, S.E. et al.
(1995) Protein Sci. 4 : 2469

Glucose Analogue Inhibitors of Glycogen Phosphorylase: The Design of Potential Drugs for Diabetes

Martin, J.L.,Veluraja, K.,Ross, K. et al.
(1991) Biochemistry 30 : 10101

Chain :

UniProt :

P00489 (PYGM_RABIT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate	2.4.1.1	UniProtKB:P11217
	left-to-right	UniProtKB:P11217

PDB ID: 1B4D

Hetero Atom Contents

Structure summary

Reaction