Brand  (β version)

PDB ID: 1B2L

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CYH Cyclohexanone PoSSuM
DTT 2,3-dihydroxy-1,4-dithiobutane PoSSuM
NDC Nicotinamide adenine dinucleotide cyclohexanone PoSSuM
Non-standard Residues
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Structure summary

Code : 1B2L   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS: TERNARY COMPLEX WITH NAD-CYCLOHEXANONE
Release Data : 1999-11-26
Compound :
mol_id molecule chains
1 ALCOHOL DEHYDROGENASE A
ec: 1.1.1.1
other_details: CYCLOHEXANONE
Source :
mol_id organism_scientific
1 Scaptodrosophila lebanonensis  (taxid:7225)
Authors : Benach, J., Atrian, S., Gonzalez-Duarte, R., Ladenstein, R.
Keywords : OXIDOREDUCTASE, DETOXIFICATION, METABOLISM, ALCOHOL DEHYDROGENASE, DROSOPHILA LEBANONENSIS, SHORT-CHAIN DEHYDROGENASES/REDUCTASES, TERNARY COMPLEX, NAD- CYCLOHEXANONE ADDUCT
Exp. method : X-RAY DIFFRACTION ( 1.6 Å )
Citation :

The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography.

Benach, J.,Atrian, S.,Gonzalez-Duarte, R.  et al.
(1999)  J.Mol.Biol.  289 : 335 - 355

PubMed: 10366509
DOI: 10.1006/jmbi.1999.2765

The Refined Crystal Structure of Drosophila Lebanonensis Alcohol Dehydrogenase at 1.9 A Resolution

Benach, J.,Atrian, S.,Gonzalez-Duarte, R.  et al.
(1998)  J.Mol.Biol.  282 : 383 - 399

Reaction

Chain : A
UniProt : P10807 (ADH_DROLE)
Reaction: EC: Evidence:
Physiological Direction:
a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) 1.1.1.1 PROSITE-ProRule:PRU10001
-
a secondary alcohol + NAD(+) = a ketone + NADH + H(+) 1.1.1.1 PROSITE-ProRule:PRU10001
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