Het-PDB Navi2 (PDB: 1B0F)

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Ligands
Code	Name		Style	Show	Link
SEI	1-{3-methyl-2-[4-(morpholine-4-carbonyl)-benzoylamino]-butyryl}-pyrrolidine-2-carboxylic acid (3,3,4,4,4-pentafluoro-1-isopropyl-2-oxo-butyl)-amide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
FUC	Alpha-L-fucopyranose
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 1B0F

Code :

1B0F PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE WITH MDL 101, 146

Release Data :

1998-11-09

Compound :

mol_id	molecule	chains	synonym
1	PROTEIN (ELASTASE)	A	HNE
	ec: 3.4.21.37

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	cell: NEUTROPHIL

Authors :

Schreuder, H.A., Metz, W.A., Peet, N.P., Pelton, J.T., Tardif, C.

Keywords :

SERINE PROTEASE, FLUOROETHYL KETONES, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 3.00 Å )

Citation :

Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.

Cregge, R.J.,Durham, S.L.,Farr, R.A. et al.
(1998) J.Med.Chem. 41 : 2461 - 2480

PubMed: 9651152
DOI: 10.1021/jm970812e

Chain :

UniProt :

P08246 (ELNE_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-\|-Xaa > Ala-\|-Xaa.	3.4.21.37	PubMed:36899106
	-	PubMed:36899106

PDB ID: 1B0F

Hetero Atom Contents

Structure summary

Reaction