Het-PDB Navi2 (PDB: 1AZS)

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Ligands
Code	Name	Link
FKP	Methylpiperazinoforskolin	PoSSuM
GSP	5'-guanosine-diphosphate-monothiophosphate	PoSSuM
MG	Magnesium ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1AZS

Code :

1AZS PDBj RCSB PDB PDBe

Header :

COMPLEX (LYASE/HYDROLASE)

Title :

COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE

Release Data :

1998-02-25

Compound :

mol_id	molecule	chains
1	VC1	A
	ec: 4.6.1.1 fragment: C1A DOMAIN OF ADENYLYL CYCLASE mutation: V476M, N-TERMINAL HEXAHISTIDINE TAG

mol_id	molecule	chains
2	IIC2	B
	ec: 4.6.1.1 fragment: C2A DOMAIN OF ADENYLYL CYCLASE

mol_id	molecule	chains	synonym
3	GS-ALPHA	C	STIMULATORY G-PROTEIN ALPHA SUBUNIT
	mutation: C-TERMINAL HEXAHISTIDINE TAG, NOT PALMITOYLATED AT AMINO TERMINUS

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Canis lupus familiaris (taxid:9615)	Dog	Escherichia coli BL21(DE3) (taxid:469008)
	strain: familiaris organ: PLASMA tissue: CARDIAC MUSCLE cellular_location: PLASMA MEMBRANE gene: ADENYLYL CYCLASE TYPE V expression_system_strain: BL21 expression_system_variant: DE3 expression_system_cellular_location: CYTOPLASM expression_system_vector_type: MULTI-COPY PLASMID expression_system_plasmid: PQE60-H6-VC1(580) expression_system_gene: GNAS

mol_id	organism_scientific	organism_common	expression_system
2	Rattus norvegicus (taxid:10116)	Norway rat	Escherichia coli BL21(DE3) (taxid:469008)
	strain: SPRAGUE-DAWLEY organ: PLASMA tissue: BRAIN cellular_location: PLASMA MEMBRANE gene: ADENYLYL CYCLASE TYPE II expression_system_strain: BL21 expression_system_variant: DE3 expression_system_cellular_location: CYTOPLASM expression_system_vector_type: MULTI-COPY PLASMID expression_system_plasmid: PQE60-ARGC-IIC2 expression_system_gene: GNAS

mol_id	organism_scientific	organism_common	expression_system
3	Bos taurus (taxid:9913)	Cattle	Escherichia coli BL21(DE3) (taxid:469008)
	variant: SHORT SPLICE FORM organ: PLASMA cellular_location: CYTOPLASM AND INNER PLASMA MEMBRANE gene: GNAS expression_system_strain: BL21 expression_system_variant: DE3 expression_system_cellular_location: CYTOPLASM expression_system_vector_type: MULTI-COPY PLASMID expression_system_plasmid: PQE60-GSALPHA-H expression_system_gene: GNAS

Authors :

Tesmer, J.J.G., Sprang, S.R.

Keywords :

COMPLEX (LYASE-HYDROLASE), HYDROLASE, SIGNAL TRANSDUCING PROTEIN, CYCLASE, EFFECTOR ENZYME, COMPLEX (LYASE-HYDROLASE) complex

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.

Tesmer, J.J.,Sunahara, R.K.,Gilman, A.G. et al.
(1997) Science 278 : 1907 - 1916

PubMed: 9417641
DOI: 10.1126/science.278.5345.1907

Chain :

UniProt :

P30803 (ADCY5_CANLF)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP = 3',5'-cyclic AMP + diphosphate	4.6.1.1	PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:1618857, PubMed:16766715, PubMed:19243146, PubMed:8428899
ATP = 3',5'-cyclic AMP + diphosphate	-

Chain :

UniProt :

P26769 (ADCY2_RAT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP = 3',5'-cyclic AMP + diphosphate	4.6.1.1	PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:1719547, PubMed:19243146, PubMed:21596131, PubMed:22906005, PubMed:24363043, PubMed:7761832
ATP = 3',5'-cyclic AMP + diphosphate	-

Chain :	C
UniProt :	P04896 (GNAS2_BOVIN)
Reaction :	-

PDB ID: 1AZS

Hetero Atom Contents

Structure summary

Reaction