Brand  (β version)

PDB ID: 1AYN

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Ligands
Code Name Style Show Link
DAO Lauric acid PoSSuM
MYR Myristic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1AYN   PDBj   RCSB PDB   PDBe
Header : VIRUS
Title : HUMAN RHINOVIRUS 16 COAT PROTEIN
Release Data : 1998-01-21
Compound :
mol_id molecule chains synonym
1 HUMAN RHINOVIRUS 16 COAT PROTEIN 1 HRV16
mutation: N-TERMINAL MYRISTOYLATION ON VP4
mol_id molecule chains synonym
2 HUMAN RHINOVIRUS 16 COAT PROTEIN 2 HRV16
mutation: N-TERMINAL MYRISTOYLATION ON VP4
mol_id molecule chains synonym
3 HUMAN RHINOVIRUS 16 COAT PROTEIN 3 HRV16
mutation: N-TERMINAL MYRISTOYLATION ON VP4
mol_id molecule chains synonym
4 HUMAN RHINOVIRUS 16 COAT PROTEIN 4 HRV16
mutation: N-TERMINAL MYRISTOYLATION ON VP4
Source :
mol_id organism_scientific expression_system
1 Human rhinovirus sp.  (taxid:169066) Homo sapiens  (taxid:9606)
strain: SEROTYPE 16
cell_line: HELA
expression_system_common: Human
mol_id organism_scientific expression_system
2 Human rhinovirus sp.  (taxid:169066) Homo sapiens  (taxid:9606)
strain: SEROTYPE 16
cell_line: HELA
expression_system_common: Human
mol_id organism_scientific expression_system
3 Human rhinovirus sp.  (taxid:169066) Homo sapiens  (taxid:9606)
strain: SEROTYPE 16
cell_line: HELA
expression_system_common: Human
mol_id organism_scientific expression_system
4 Human rhinovirus sp.  (taxid:169066) Homo sapiens  (taxid:9606)
strain: SEROTYPE 16
cell_line: HELA
expression_system_common: Human
Authors : Hadfield, A.T., Oliveira, M.A., Zhao, R., Rossmann, M.G.
Keywords : HUMAN RHINOVIRUS 16, RECEPTOR, DRUG, RHINOVIRUS COAT PROTEIN, Icosahedral virus, Virus
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

The structure of human rhinovirus 16.

Oliveira, M.A.,Zhao, R.,Lee, W.M.  et al.
(1993)  Structure  1 : 51 - 68

PubMed: 7915182
DOI: 10.1016/0969-2126(93)90008-5

The Refined Structure of Human Rhinovirus 16 at 2.15 Angstroms Resolution: Implications for the Viral Life Cycle

Hadfield, A.T.,Lee, W.M.,Zhao, R.  et al.
(1997)  Structure  5 : 427

Structure of a Human Rhinovirus Complexed with its Receptor Molecule

Olson, N.H.,Kolatkar, P.R.,Oliveira, M.A.  et al.
(1993)  Proc.Natl.Acad.Sci.USA  90 : 507

A Comparison of the Anti-Rhinoviral Drug Binding Pocket in Hrv14 and Hrv1A

Kim, K.H.,Willingmann, P.,Gong, Z.X.  et al.
(1993)  J.Mol.Biol.  230 : 206

Crystal Structure of Human Rhinovirus Serotype 1A (Hrv1A)

Kim, S.S.,Smith, T.J.,Chapman, M.S.  et al.
(1989)  J.Mol.Biol.  210 : 91

Common Cold Viruses

Rossmann, M.G.,Arnold, E.,Griffith, J.P.  et al.
(1987)  Trends Biochem.Sci.  12 : 313

The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents that Inhibit Uncoating

Smith, T.J.,Kremer, M.J.,Luo, M.  et al.
(1986)  Science  233 : 1286

Structure of a Human Common Cold Virus and Functional Relationship to Other Picornaviruses

Rossmann, M.G.,Arnold, E.,Erickson, J.W.  et al.
(1985)  Nature  317 : 145

Reaction

Chain : 3
UniProt : Q82122 (POLG_HRV16)
Reaction: EC: Evidence:
Physiological Direction:
[Protein 2C]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 UniProtKB:P03300
-
[Protease 2A]
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 		3.4.22.29 UniProtKB:P03300
-
[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539
-
[Protease 3C]
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 		3.4.22.28 PROSITE-ProRule:PRU01222
-
Chain : 4
UniProt : P23008 (POLG_HRV1A)
Reaction: EC: Evidence:
Physiological Direction:
[Protein 2C]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 UniProtKB:P03300
-
[Protease 2A]
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 		3.4.22.29 UniProtKB:P03300
-
[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539
-
[Protease 3C]
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 		3.4.22.28 PROSITE-ProRule:PRU01222
-