Brand  (β version)

PDB ID: 1AX4

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Ligands
Code Name Style Show Link
K Potassium ion PoSSuM
Non-standard Residues
Code Name Show
LLP (2s)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid
Glycosylation
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Modification
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Structure summary

Code : 1AX4   PDBj   RCSB PDB   PDBe
Header : TRYPTOPHAN BIOSYNTHESIS
Title : TRYPTOPHANASE FROM PROTEUS VULGARIS
Release Data : 1998-01-28
Compound :
mol_id molecule chains synonym
1 TRYPTOPHANASE A,B,C,D TRYPTOPHAN INDOLE-LYASE
ec: 4.1.99.1
other_details: PYRIDOXAL 5'-DEPENDENT ENZYME, REQUIRES MONOVALENT CATIONS FOR ACTIVITY, DEGRADES L-TRYPTOPHAN TO INDOLE, PYRUVATE AND AMMONIA
Source :
mol_id organism_scientific expression_system
1 Proteus vulgaris  (taxid:585) Escherichia coli  (taxid:562)
Authors : Isupov, M.N., Antson, A.A., Dodson, E.J., Dodson, G.G., Dementieva, I.S., Zakomirdina, L.N., Wilson, K.S., Dauter, Z., Lebedev, A.A., Harutyunyan, E.H.
Keywords : TRYPTOPHAN BIOSYNTHESIS, TRYPTOPHAN INDOLE-LYASE, PYRIDOXAL 5'-PHOSPHATE, MONOVALENT CATION BINDING SITE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Crystal structure of tryptophanase.

Isupov, M.N.,Antson, A.A.,Dodson, E.J.  et al.
(1998)  J.Mol.Biol.  276 : 603 - 623

PubMed: 9551100
DOI: 10.1006/jmbi.1997.1561

X-Ray Study of Tryptophanase at 2.1 Angstrom Resolution

Isupov, M.,Dementieva, I.,Zakomirdina, L.  et al.
(1994)  Biochemistry of Vitamin B6 and Pqq  : 183

Crystallization and Preliminary X-Ray Investigation of Holotryptophanases from Escherichia Coli and Proteus Vulgaris

Dementieva, I.S.,Zakomirdina, L.N.,Sinitzina, N.I.  et al.
(1994)  J.Mol.Biol.  235 : 783

Reaction

Chain : A, B, C, D
UniProt : P28796 (TNAA_PROVU)
Reaction: EC: Evidence:
Physiological Direction:
L-tryptophan + H2O = indole + pyruvate + NH4(+) 4.1.99.1 -
-
Cofactor: Evidence: Note:
pyridoxal 5'-phosphate - -