Brand  (β version)

PDB ID: 1AUK

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
Non-standard Residues
Code Name Show
FGL 2-aminopropanedioic acid
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 1AUK   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : HUMAN ARYLSULFATASE A
Release Data : 1998-03-04
Compound :
mol_id molecule chains synonym
1 ARYLSULFATASE A A CEREBROSIDE-3-SULFATE-SULFATASE
ec: 3.1.6.8
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Mesocricetus auratus  (taxid:10036)
organ: TESTIS
cellular_location: LYSOSOME
gene: ARSA
expression_system_common: Golden hamster
expression_system_cell_line: BABY HAMSTER KIDNEY CELLS (BHK)
expression_system_cellular_location: SECRETED ENZYME
expression_system_vector_type: PLASMID
expression_system_plasmid: PBEH
other_details: C-DNA EXPRESSION
Authors : Lukatela, G., Krauss, N., Theis, K., Gieselmann, V., Von Figura, K., Saenger, W.
Keywords : CEREBROSIDE-3-SULFATE HYDROLYSIS, LYSOSOMAL ENZYME, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis.

Lukatela, G.,Krauss, N.,Theis, K.  et al.
(1998)  Biochemistry  37 : 3654 - 3664

PubMed: 9521684
DOI: 10.1021/bi9714924

Reaction

Chain : A
UniProt : P15289 (ARSA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate 3.1.6.8 PubMed:10751093, PubMed:24294900
left-to-right PubMed:24294900