Brand  (β version)

PDB ID: 1ATL

Hetero Atom Contents

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Code Name Style Show Link
ZN Zinc ion PoSSuM
CA Calcium ion PoSSuM
0QI O-methyl-N-[(2s)-4-methyl-2-(sulfanylmethyl)pentanoyl]-L-tyrosine PoSSuM

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Glycosylation
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Structure summary

Code : 1ATL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Structural interaction of natural and synthetic inhibitors with the VENOM METALLOPROTEINASE, ATROLYSIN C (FORM-D)
Release Data : 1995-10-15
Compound :
mol_id molecule chains synonym
1 Snake venom metalloproteinase atrolysin-D A,B SVMP,Hemorrhagic metalloproteinase atrolysin D,Hemorrhagic toxin D,HT-D
ec: 3.4.24.42
Source :
mol_id organism_scientific organism_common
1 Crotalus atrox  (taxid:8730) Western diamondback rattlesnake
other_details: ISOLATED FROM VENOM
Authors : Zhang, D., Botos, I., Gomis-Rueth, F.-X., Doll, R., Blood, C., Njoroge, F.G., Fox, J.W., Bode, W., Meyer, E.F.
Keywords : METALLOENDOPEPTIDASE, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d).

Zhang, D.,Botos, I.,Gomis-Ruth, F.X.  et al.
(1994)  Proc.Natl.Acad.Sci.USA  91 : 8447 - 8451

PubMed: 8078901
DOI: 10.1073/pnas.91.18.8447

Structure of a Retro-Binding Peptide Inhibitor Complexed with Human Alpha-Thrombin

Tabernero, L.,Chang, C.Y.,Ohringer, S.L.  et al.
(1995)  J.Mol.Biol.  246 : 14

Reaction

Chain : A, B
UniProt : P15167 (VM1AD_CROAT)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 of insulin B chain. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1. 3.4.24.42 -
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000250
Binds 1 zinc ion per subunit.