Brand  (β version)

PDB ID: 1AR6

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Ligands
Code Name Style Show Link
MYR Myristic acid PoSSuM
SPH Sphingosine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1AR6   PDBj   RCSB PDB   PDBe
Header : VIRUS
Title : P1/MAHONEY POLIOVIRUS, DOUBLE MUTANT V1160I +P1095S
Release Data : 1997-12-03
Compound :
mol_id molecule chains
1 P1/MAHONEY POLIOVIRUS 0
fragment: VIRUS PROTOMER
mutation: CHAIN 1, P95S, V160I
mol_id molecule chains
2 P1/MAHONEY POLIOVIRUS 1
fragment: VIRUS PROTOMER
mutation: CHAIN 1, P95S, V160I
mol_id molecule chains
3 P1/MAHONEY POLIOVIRUS 2
fragment: VIRUS PROTOMER
mutation: CHAIN 1, P95S, V160I
mol_id molecule chains
4 P1/MAHONEY POLIOVIRUS 3
fragment: VIRUS PROTOMER
mutation: CHAIN 1, P95S, V160I
mol_id molecule chains
5 P1/MAHONEY POLIOVIRUS 4
fragment: VIRUS PROTOMER
mutation: CHAIN 1, P95S, V160I
Source :
mol_id organism_scientific
1 Human poliovirus 1  (taxid:12081)
strain: Mahoney
mol_id organism_scientific
2 Human poliovirus 1  (taxid:12081)
strain: Mahoney
mol_id organism_scientific
3 Human poliovirus 1  (taxid:12081)
strain: Mahoney
mol_id organism_scientific
4 Human poliovirus 1  (taxid:12081)
strain: Mahoney
mol_id organism_scientific
5 Human poliovirus 1  (taxid:12081)
strain: Mahoney
Authors : Wien, M.W., Curry, S., Filman, D.J., Hogle, J.M.
Keywords : PICORNAVIRUS, POLIOVIRUS, COAT PROTEIN, Icosahedral virus, Virus
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

Structural studies of poliovirus mutants that overcome receptor defects.

Wien, M.W.,Curry, S.,Filman, D.J.  et al.
(1997)  Nat.Struct.Biol.  4 : 666 - 674

PubMed: 9253417
DOI: 10.1038/nsb0897-666

A Pseudo-Cell Based Approach to Efficient Crystallographic Refinement of Viruses

Jacobson, D.H.,Hogle, J.M.,Filman, D.J.
(1996)  Acta Crystallogr.,Sect.D  52 : 693

Three-Dimensional Structure of Poliovirus at 2.9 A Resolution

Hogle, J.M.,Chow, M.,Filman, D.J.
(1985)  Science  229 : 1358

Reaction

Chain : 3
UniProt : P03300 (POLG_POL1M)
Reaction: EC: Evidence:
Physiological Direction:
[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539
-
[Protease 2A]
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 		3.4.22.29 PubMed:1649327
-
[Protein 2C]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 PubMed:19520852, PubMed:30231078, PubMed:7730315, PubMed:8385138
-
[Protease 3C]
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 		3.4.22.28 PROSITE-ProRule:PRU01222, PubMed:8097606
-
Chain : 4
UniProt : P03299 (POLG_POL1M)
Reaction: EC: Evidence:
Physiological Direction:
[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539
-
[Protease 2A]
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 		3.4.22.29 PubMed:1649327
-
[Protein 2C]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 PubMed:19520852, PubMed:30231078, PubMed:7730315, PubMed:8385138
-
[Protease 3C]
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 		3.4.22.28 PROSITE-ProRule:PRU01222, PubMed:8097606
-