Brand  (β version)

PDB ID: 1AQW

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Ligands
Code Name Style Show Link
GSH Glutathione PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1AQW   PDBj   RCSB PDB   PDBe
Header : transferase/substrate
Title : GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE
Release Data : 1998-03-18
Compound :
mol_id molecule chains synonym
1 GLUTATHIONE S-TRANSFERASE A,B,C,D GST
ec: 2.5.1.18
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
organ: PLACENTA
cellular_location: CYTOSOL
gene: GTP_HUMAN
Authors : Prade, L., Huber, R., Manoharan, T.H., Fahl, W.E., Reuter, W.
Keywords : TRANSFERASE, GLUTATHIONE S-TRANSFERASE, CLASS PI, transferase-substrate complex
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor.

Prade, L.,Huber, R.,Manoharan, T.H.  et al.
(1997)  Structure  5 : 1287 - 1295

PubMed: 9351803
DOI: 10.1016/S0969-2126(97)00281-5

Three-Dimensional Structure of Class Pi Glutathione S-Transferase from Human Placenta in Complex with S-Hexylglutathione at 2.8 A Resolution

Reinemer, P.,Dirr, H.W.,Ladenstein, R.  et al.
(1992)  J.Mol.Biol.  227 : 214

Reaction

Chain : A, B, C, D
UniProt : P09211 (GSTP1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
glutathione + RX = a halide anion + an S-substituted glutathione + H(+) 2.5.1.18 PubMed:1540159, PubMed:1567427, PubMed:8433974
left-to-right ECO:0000305
glutathione + prostaglandin J2 = prostaglandin J2-S-(R)- glutathione - PubMed:9084911
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glutathione + prostaglandin J2 = prostaglandin J2-S-(S)- glutathione - PubMed:9084911
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glutathione + prostaglandin A2 = prostaglandin A2-S-(S)- glutathione - PubMed:9084911
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11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)- eicosatrienoate - PubMed:21046276
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