Brand  (β version)

PDB ID: 1AQ2

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Ligands
Code Name Style Show Link
ATP Adenosine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
MN Manganese (II) ion PoSSuM
PYR Pyruvic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1AQ2   PDBj   RCSB PDB   PDBe
Header : KINASE
Title : PHOSPHOENOLPYRUVATE CARBOXYKINASE
Release Data : 1998-10-14
Compound :
mol_id molecule chains synonym
1 PHOSPHOENOLPYRUVATE CARBOXYKINASE A ATP-OXALOACETATE CARBOXY-LYASE (ATP)
ec: 4.1.1.49
other_details: ORDERED MAGNESIUM AND MANGANESE IONS OBSERVED BOUND TO ATP
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
cellular_location: CYTOPLASM
expression_system_gene: PCKA
other_details: NATIVE PROMOTER OF E. COLI PCKA GENE, HIGHLY AEROBIC GROWTH TO EARLY STATIONARY PHASE IN THE ABSENCE OF CARBOHYDRATES
Authors : Tari, L.W., Matte, A., Goldie, H., Delbaere, L.T.J.
Keywords : KINASE, TRANSPHOSPHORYLATING, P-LOOP, PROTEIN-ATP COMPLEX, NUCLEOTIDE-TRIPHOSPHATE HYDROLASE, LYASE, GLUCONEOGENESIS
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Mg(2+)-Mn2+ clusters in enzyme-catalyzed phosphoryl-transfer reactions.

Tari, L.W.,Matte, A.,Goldie, H.  et al.
(1997)  Nat.Struct.Biol.  4 : 990 - 994

PubMed: 9406547
DOI: 10.1038/nsb1297-990

Crystal Structure of Escherichia Coli Phosphoenolpyruvate Carboxykinase: A New Structural Family with the P-Loop Nucleoside Triphosphate Hydrolase Fold

Matte, A.,Goldie, H.,Sweet, R.M.  et al.
(1996)  J.Mol.Biol.  256 : 126

Snapshot of an Enzyme Reaction Intermediate in the Structure of the ATP-Mg2+-Oxalate Ternary Complex of Escherichia Coli Pep Carboxykinase

Tari, L.W.,Matte, A.,Pugazhenthi, U.  et al.
(1996)  Nat.Struct.Biol.  3 : 355

Crystallization of the Calcium-Activated Phosphoenolpyruvate Carboxykinase from Escherichia Coli K12

Delbaere, L.T.,Vandonselaar, M.,Glaeske, D.  et al.
(1991)  J.Mol.Biol.  219 : 593

Sequence of the Pcka Gene of Escherichia Coli K-12: Relevance to Genetic and Allosteric Regulation and Homology of E. Coli Phosphoenolpyruvate Carboxykinase with the Enzymes from Trypanosoma Brucei and Saccharomyces Cerevisiae

Medina, V.,Pontarollo, R.,Glaeske, D.  et al.
(1990)  J.Bacteriol.  172 : 7151

Reaction

Chain : A
UniProt : P22259 (PCKA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate 4.1.1.49 HAMAP-Rule:MF_00453, PubMed:6986370
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