Het-PDB Navi2 (PDB: 1AN1)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
CA	Calcium ion				PoSSuM

Non-standard Residues
Code	Name	Show
DAS	D-aspartic acid

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1AN1

Code :

1AN1 PDBj RCSB PDB PDBe

Header :

COMPLEX (SERINE PROTEASE/INHIBITOR)

Title :

LEECH-DERIVED TRYPTASE INHIBITOR/TRYPSIN COMPLEX

Release Data :

1998-07-01

Compound :

mol_id	molecule	chains	synonym
1	TRYPSIN	E	LDTI

mol_id	molecule	chains
2	TRYPTASE INHIBITOR	I
	ec: 3.4.21.4 mutation: N115D (D-ASPARTIC ACID FORM)

Source :

mol_id	organism_scientific	organism_common
1	Sus scrofa (taxid:9823)	Pig
	organ: PANCREAS

mol_id	organism_scientific	organism_common	expression_system
2	Hirudo medicinalis (taxid:6421)	Medicinal leech	Saccharomyces cerevisiae (taxid:4932)
	organ: SALIVARY GLANDS expression_system_common: Baker's yeast expression_system_strain: H449 expression_system_variant: TR1376, TR1417 expression_system_plasmid: PDP34

Authors :

Priestle, J.P., Di Marco, S.

Keywords :

SERINE PROTEINASE INHIBITOR, TRYPTASE INHIBITION, NON-CLASSICAL KAZAL-TYPE INHIBITOR, COMPLEX (SERINE PROTEASE-INHIBITOR), COMPLEX (SERINE PROTEASE-INHIBITOR) complex

Exp. method :

X-RAY DIFFRACTION ( 2.03 Å )

Citation :

Structure of the complex of leech-derived tryptase inhibitor (LDTI) with trypsin and modeling of the LDTI-tryptase system.

Di Marco, S.,Priestle, J.P.
(1997) Structure 5 : 1465 - 1474

PubMed: 9384562
DOI: 10.1016/S0969-2126(97)00296-7

Purification, Characterization and Biological Evaluation of Recombinant Leech-Derived Tryptase Inhibitor (Rldti) Expressed at High Level in the Yeast Saccharomyces Cerevisiae

Pohlig, G.,Fendrich, G.,Knecht, R. et al.
(1996) Eur.J.Biochem. 241 : 619

A Kazal-Type Inhibitor of Human Mast Cell Tryptase: Isolation from the Medical Leech Hirudo Medicinalis, Characterization, and Sequence Analysis

Sommerhoff, C.P.,Sollner, C.,Mentele, R. et al.
(1994) Biol.Chem.Hoppe-Seyler 375 : 685

Chain :

UniProt :

P00761 (TRYP_PIG)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Preferential cleavage: Arg-\|-Xaa, Lys-\|-Xaa.	3.4.21.4	-
Preferential cleavage: Arg-\|-Xaa, Lys-\|-Xaa.	-	-

Chain :	I
UniProt :	P80424 (LDTI_HIRME)
Reaction :	-

PDB ID: 1AN1

Hetero Atom Contents

Structure summary

Reaction