Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CO3 Carbonate ion
SO4 Sulfate ion
Code : 1ALQ
Header : HYDROLASE
Title : CIRCULARLY PERMUTED BETA-LACTAMASE FROM STAPHYLOCOCCUS AUREUS PC1
Release Data : 1997-09-26
Compound :
mol_id molecule chains
1 CP254 BETA-LACTAMASE A
ec: 3.5.2.6
mutation: CIRCULARLY PERMUTED WITH AN EIGHT RESIDUE LINKER INSERTED TO JOIN THE ORIGINAL N- AND C-TERMINI, AND A NEW N-TERMINUS AT RESIDUE 254
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus  (taxid:1280) Escherichia coli  (taxid:562)
cell_line: 293
expression_system_strain: TG1
expression_system_vector_type: BACTERIAL
Authors : Pieper, U., Herzberg, O.
Keywords : HYDROLASE, CIRCULAR PERMUTED, ANTIBIOTIC RESISTANCE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Circularly permuted beta-lactamase from Staphylococcus aureus PC1.

Pieper, U.,Hayakawa, K.,Li, Z.  et al.
(1997)  Biochemistry  36 : 8767 - 8774

PubMed: 9220963
DOI: 10.1021/bi9705117

Refined Crystal Structure of Beta-Lactamase from Staphylococcus Aureus Pc1 at 2.0 A Resolution

Herzberg, O.
(1991)  J.Mol.Biol.  217 : 701

Bacterial Resistance to Beta-Lactam Antibiotics: Crystal Structure of Beta-Lactamase from Staphylococcus Aureus Pc1 at 2.5 A Resolution

Herzberg, O.,Moult, J.
(1987)  Science  236 : 694

Chain : A
UniProt : P00807 (BLAC_STAAU)
Reaction : A beta-lactam + H(2)O = a substituted beta- amino acid.