Brand  (β version)

PDB ID: 1AIQ

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Ligands
Code Name Style Show Link
CB3 10-propargyl-5,8-dideazafolic acid PoSSuM
UMP 2'-deoxyuridine 5'-monophosphate PoSSuM
Non-standard Residues
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CXM N-carboxymethionine
Glycosylation
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Structure summary

Code : 1AIQ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE R126E MUTANT
Release Data : 1997-11-12
Compound :
mol_id molecule chains synonym
1 THYMIDYLATE SYNTHASE A,B TRANSFERASE
ec: 2.1.1.45
mutation: R126E
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_strain: XAC25 THY- STRAIN
expression_system_plasmid: BLUSCRIPT SK+
Authors : Strop, P., Montfort, W.R.
Keywords : TRANSFERASE, METHYLTRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.

Strop, P.,Changchien, L.,Maley, F.  et al.
(1997)  Protein Sci.  6 : 2504 - 2511

PubMed: 9416600

Reaction

Chain : A, B
UniProt : P0A884 (TYSY_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP 2.1.1.45 HAMAP-Rule:MF_00008, PubMed:2223754, PubMed:3286637, PubMed:9826509
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