Brand  (β version)

PDB ID: 1AIO

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Ligands
Code Name Style Show Link
CPT Cisplatin PoSSuM
Non-standard Residues
Code Name Show
BRU 5-bromo-2'-deoxyuridine-5'-monophosphate
Glycosylation
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Modification
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Structure summary

Code : 1AIO   PDBj   RCSB PDB   PDBe
Header : DNA
Title : CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN
Release Data : 1997-04-24
Compound :
mol_id molecule chains
1 DNA (5'-D(*CP*CP*(BRU)P*CP*TP*[PT(NH3)2(GP*GP)]*TP*CP*TP*CP*C)-3') A,C
mol_id molecule chains
2 DNA (5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3') B,D
Source :
mol_id organism_scientific
1
mol_id organism_scientific
2
Authors : Takahara, P.M., Rosenzweig, A.C., Frederick, C.A., Lippard, S.J.
Keywords : RIGHT HANDED DNA, DOUBLE HELIX, COMPLEXED WITH DRUG, MODIFIED, DNA
Exp. method : X-RAY DIFFRACTION ( 2.600 Å )
Citation :

Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin.

Takahara, P.M.,Rosenzweig, A.C.,Frederick, C.A.  et al.
(1995)  Nature  377 : 649 - 652

PubMed: 7566180
DOI: 10.1038/377649a0

Crystal Structure of the Anticancer Drug Cisplatin Bound to Duplex DNA

Takahara, P.M.,Frederick, C.A.,Lippard, S.J.
(1996)  J.Am.Chem.Soc.  118 : 12309 - 12321