Brand  (β version)

PDB ID: 1AI9

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Ligands
Code Name Style Show Link
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1AI9   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE
Release Data : 1997-11-12
Compound :
mol_id molecule chains synonym
1 DIHYDROFOLATE REDUCTASE A,B DHFR
ec: 1.5.1.3
other_details: ACTS AS A MONOMER WITH NADPH
Source :
mol_id organism_scientific expression_system
1 Candida albicans  (taxid:5476) Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21
expression_system_variant: DE3
expression_system_cellular_location: CYTOPLASM
expression_system_vector_type: PLASMID
Authors : Whitlow, M., Howard, A.J., Stewart, D.
Keywords : OXIDOREDUCTASE, ANTIFUNGAL TARGET, REDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex.

Whitlow, M.,Howard, A.J.,Stewart, D.  et al.
(1997)  J.Biol.Chem.  272 : 30289 - 30298

PubMed: 9374515
DOI: 10.1074/jbc.272.48.30289

Characterization of Candida Albicans Dihydrofolate Reductase

Baccanari, D.P.,Tansik, R.L.,Joyner, S.S.  et al.
(1989)  J.Biol.Chem.  264 : 1100

Reaction

Chain : A, B
UniProt : P22906 (DYR_CANAX)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH 1.5.1.3 PROSITE- ProRule:PRU00660
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