Brand  (β version)

PDB ID: 1AI8

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Ligands
Code Name Style Show Link
T42 Morpholino-diphenylalanine-methoxypropylboronic acid PoSSuM
Non-standard Residues
Code Name Show
TYS O-sulfo-L-tyrosine
Glycosylation
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Structure summary

Code : 1AI8   PDBj   RCSB PDB   PDBe
Header : BLOOD COAGULATION/HYDROLASE INHIBITOR
Title : HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG
Release Data : 1997-10-15
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN (SMALL SUBUNIT) L
ec: 3.4.21.5
mol_id molecule chains
2 ALPHA-THROMBIN (LARGE SUBUNIT) H
ec: 3.4.21.5
mol_id molecule chains
3 HIRUDIN IIIB I
ec: 3.4.21.5
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
3 Hirudo medicinalis  (taxid:6421) Medicinal leech
Authors : Skordalakes, E., Dodson, G., Elgendy, S., Goodwin, C.A., Green, D., Tyrrel, R., Scully, M.F., Freyssinet, J., Kakkar, V.V., Deadman, J.
Keywords : SERINE PROTEINASE, BLOOD COAGULATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, BLOOD COAGULATION-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.

Bode, W.,Turk, D.,Karshikov, A.
(1992)  Protein Sci.  1 : 426 - 471

PubMed: 1304349

The Refined 1.9 A Crystal Structure of Human Alpha-Thrombin: Interaction with D-Phe-Pro-Arg Chloromethylketone and Significance of the Tyr-Pro-Pro-Trp Insertion Segment

Bode, W.,Mayr, I.,Baumann, U.  et al.
(1989)  Embo J.  8 : 3467

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P28501 (HIRV1_HIRME)
Reaction : -