Het-PDB Navi2 (PDB: 1AI7)

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Ligands
Code	Name		Style	Show	Link
CA	Calcium ion				PoSSuM
IPH	Phenol				PoSSuM

Non-standard Residues
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Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1AI7

Code :

1AI7 PDBj RCSB PDB PDBe

Header :

ANTIBIOTIC RESISTANCE

Title :

PENICILLIN ACYLASE COMPLEXED WITH PHENOL

Release Data :

1997-11-12

Compound :

mol_id	molecule	chains
1	PENICILLIN AMIDOHYDROLASE	A
	ec: 3.5.1.11

mol_id	molecule	chains
2	PENICILLIN AMIDOHYDROLASE	B
	ec: 3.5.1.11

Source :

mol_id	organism_scientific
1	Escherichia coli (taxid:562)
	atcc: 11105

mol_id	organism_scientific
2	Escherichia coli (taxid:562)
	atcc: 11105

Authors :

Done, S.H.

Keywords :

ANTIBIOTIC RESISTANCE, LIGAND INDUCED CONFORMATIONAL CHANGE, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Ligand-induced conformational change in penicillin acylase.

Done, S.H.,Brannigan, J.A.,Moody, P.C.E. et al.
(1998) J.Mol.Biol. 284 : 463 - 475

PubMed: 9813130
DOI: 10.1006/jmbi.1998.2180

Structural Studies of Penicillin Acylase

Done, S.H.
(1996) Thesis

Penicillin Acylase Has a Single-Amino-Acid Catalytic Centre

Duggleby, H.J.,Tolley, S.P.,Hill, C.P. et al.
(1995) Nature 373 : 264

Expression, Purification and Crystallization of Penicillin G Acylase from Escherichia Coli Atcc 11105

Hunt, P.D.,Tolley, S.P.,Ward, R.J. et al.
(1990) Protein Eng. 3 : 635

Chain :

UniProt :

P06875 (PAC_ECOLX)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a penicillin + H2O = 6-aminopenicillanate + a carboxylate	3.5.1.11	-
a penicillin + H2O = 6-aminopenicillanate + a carboxylate	-	-

PDB ID: 1AI7

Hetero Atom Contents

Structure summary

Reaction