Brand  (β version)

PDB ID: 1AI7

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
IPH Phenol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1AI7   PDBj   RCSB PDB   PDBe
Header : ANTIBIOTIC RESISTANCE
Title : PENICILLIN ACYLASE COMPLEXED WITH PHENOL
Release Data : 1997-11-12
Compound :
mol_id molecule chains
1 PENICILLIN AMIDOHYDROLASE A
ec: 3.5.1.11
mol_id molecule chains
2 PENICILLIN AMIDOHYDROLASE B
ec: 3.5.1.11
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
atcc: 11105
mol_id organism_scientific
2 Escherichia coli  (taxid:562)
atcc: 11105
Authors : Done, S.H.
Keywords : ANTIBIOTIC RESISTANCE, LIGAND INDUCED CONFORMATIONAL CHANGE, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Ligand-induced conformational change in penicillin acylase.

Done, S.H.,Brannigan, J.A.,Moody, P.C.E.  et al.
(1998)  J.Mol.Biol.  284 : 463 - 475

PubMed: 9813130
DOI: 10.1006/jmbi.1998.2180

Structural Studies of Penicillin Acylase

Done, S.H.
(1996)  Thesis 

Penicillin Acylase Has a Single-Amino-Acid Catalytic Centre

Duggleby, H.J.,Tolley, S.P.,Hill, C.P.  et al.
(1995)  Nature  373 : 264

Expression, Purification and Crystallization of Penicillin G Acylase from Escherichia Coli Atcc 11105

Hunt, P.D.,Tolley, S.P.,Ward, R.J.  et al.
(1990)  Protein Eng.  3 : 635

Reaction

Chain : B
UniProt : P06875 (PAC_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
a penicillin + H2O = 6-aminopenicillanate + a carboxylate 3.5.1.11 -
-
Cofactor: Evidence: Note:
Ca(2+) - Binds 1 Ca(2+) ion per dimer.