Het-PDB Navi2 (PDB: 1AI2)

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Ligands
Code	Name		Style	Show	Link
ICA	Isocitrate calcium complex				PoSSuM
NAP	Nadp nicotinamide-adenine-dinucleotide phosphate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1AI2

Code :

1AI2 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

ISOCITRATE DEHYDROGENASE COMPLEXED WITH ISOCITRATE, NADP+, AND CALCIUM (FLASH-COOLED)

Release Data :

1997-10-15

Compound :

mol_id	molecule	chains	synonym
1	ISOCITRATE DEHYDROGENASE	A	OXALOSUCCINATE DECARBOXYLASE, IDH
	ec: 1.1.1.42

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	cell_line: DEK2004 expression_system_plasmid: PICD

Authors :

Stoddard, B.L., Mesecar, A., Koshland Junior, D.E.

Keywords :

OXIDOREDUCTASE (NAD(A)-CHOH(D)), NADP, PHOSPHORYLATION, GLYOXYLATE BYPASS, OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 1.9 Å )

Citation :

Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.

Mesecar, A.D.,Stoddard, B.L.,Koshland Jr., D.E.
(1997) Science 277 : 202 - 206

PubMed: 9211842
DOI: 10.1126/science.277.5323.202

Determinants of Cofactor Specificity in Isocitrate Dehydrogenase: Structure of an Engineered Nadp+--> Nad+ Specificity-Reversal Mutant

Hurley, J.H.,Chen, R.,Dean, A.M.
(1996) Biochemistry 35 : 5670

Structure of Isocitrate Dehydrogenase with Isocitrate, Nicotinamide Adenine Dinucleotide Phosphate, and Calcium at 2.5-A Resolution: A Pseudo-Michaelis Ternary Complex

Stoddard, B.L.,Dean, A.,Koshland Junior, D.E.
(1993) Biochemistry 32 : 9310

Chain :

UniProt :

P08200 (IDH_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH	1.1.1.42	PubMed:21151122, PubMed:3112144, PubMed:7761851, PubMed:7819221
D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH	-

PDB ID: 1AI2

Hetero Atom Contents

Structure summary

Reaction