Brand  (β version)

PDB ID: 1AH4

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Ligands
Code Name Style Show Link
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
Code Name Show
AYA N-acetylalanine
Glycosylation
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Modification
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Structure summary

Code : 1AH4   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : PIG ALDOSE REDUCTASE, HOLO FORM
Release Data : 1998-04-15
Compound :
mol_id molecule chains
1 ALDOSE REDUCTASE A
ec: 1.1.1.21
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
organ: EYE
tissue: LENS
Authors : Moras, D., Podjarny, A.
Keywords : OXIDOREDUCTASE, ALDOSE REDUCTASE, INHIBITION, DIABETES
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.

Urzhumtsev, A.,Tete-Favier, F.,Mitschler, A.  et al.
(1997)  Structure  5 : 601 - 612

PubMed: 9195881
DOI: 10.1016/S0969-2126(97)00216-5

Aldose Reductase from Pig Lens

Tete-Favier, F.,Barth, P.,Mitschler, A.  et al.
(1995)  Eur.J.Med.Chem.  30S : 589

Structure Determination of Aldose Reductase: Joys and Traps of Local Symmetry Averaging

Tete-Favier, F.,Rondeau, J.-M.,Podjarny, A.  et al.
(1993)  Acta Crystallogr.,Sect.D  49 : 246

Novel Nadph-Binding Domain Revealed by the Crystal Structure of Aldose Reductase

Rondeau, J.M.,Tete-Favier, F.,Podjarny, A.  et al.
(1992)  Nature  355 : 469

Reaction

Chain : A
UniProt : P80276 (ALDR_PIG)
Reaction: EC: Evidence:
Physiological Direction:
an alditol + NADP(+) = an aldose + H(+) + NADPH 1.1.1.21 UniProtKB:P15121
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all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH 1.1.1.300 UniProtKB:P15121
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9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH - UniProtKB:P15121
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13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH - UniProtKB:P15121
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glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH 1.1.1.372 UniProtKB:P15121
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glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH 1.1.1.372 UniProtKB:P15121
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NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH - UniProtKB:P15121
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(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + H(+) + NADPH - UniProtKB:P15121
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(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH - UniProtKB:P15121
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a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH - UniProtKB:P15121
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NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin H2 - UniProtKB:P15121
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allyl alcohol + NADP(+) = acrolein + H(+) + NADPH 1.1.1.54 UniProtKB:P15121
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NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3- carbaldehyde - UniProtKB:P15121
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1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3- phosphocholine + NADP(+) - UniProtKB:P15121
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1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3- phosphocholine + NADP(+) - UniProtKB:P15121
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1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3- phosphocholine + NADP(+) - UniProtKB:P15121
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1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3- phosphoethanolamine + H(+) + NADPH = 1-hexadecanoyl-2-(5- hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+) - UniProtKB:P15121
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