Brand  (β version)

PDB ID: 1AGU

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
E N-((-)-(7s,8r,9s,10r)[7,8,9-trihydroxy-7,8,9,10-tetra hydrobenzo[a]pyren-10-yl])-2'-deoxy-adenosine-5'-monophosphate
Glycosylation
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Modification
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Structure summary

Code : 1AGU   PDBj   RCSB PDB   PDBe
Header : DNA
Title : THE SOLUTION NMR STRUCTURE OF THE C10R ADDUCT OF BENZO[A]PYRENE-DIOL-EPOXIDE AT THE N6 POSITION OF ADENINE OF AN 11 BASE-PAIR OLIGONUCLEOTIDE SEQUENCE CODING FOR AMINO ACIDS 60-62 OF THE PRODUCT OF THE N-RAS PROTOONCOGENE, MINIMIZED AVERAGE STRUCTURE
Release Data : 1997-08-20
Compound :
mol_id molecule chains
1 DNA (5'-D(*CP*GP*GP*AP*CP*EP*AP*GP*AP*AP*G)-3') A
other_details: C10R-BPDE-N6-ADENINE ADDUCT
mol_id molecule chains
2 DNA (5'-D(*CP*TP*TP*CP*TP*TP*GP*TP*CP*CP*G)-3') B
other_details: C10R-BPDE-N6-ADENINE ADDUCT
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
Authors : Zegar, I.S., Stone, M.P.
Keywords : DNA DUPLEX, HUMAN N-RAS GENE, CODON 61 SEQUENCE, C10R-BPDE ADDUCT, INTERCALATION, N6-ADENINE ADDUCT, DEOXYRIBONUCLEIC ACID, DNA
Exp. method : SOLUTION NMR
Citation :

Adduction of the human N-ras codon 61 sequence with (-)-(7S,8R,9R,10S)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a] pyrene: structural refinement of the intercalated SRSR(61,2) (-)-(7S,8R,9S,1 0R)-N6-[10-(7,8,9,10- tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct from 1H NMR

Zegar, I.S.,Kim, S.J.,Johansen, T.N.  et al.
(1996)  Biochemistry  35 : 6212 - 6224

PubMed: 8639561
DOI: 10.1021/bi9524732

Solution Structure of an Oligodeoxynucleotide Containing the Human N-Ras Codon 61 Sequence Refined from 1H NMR Using Molecular Dynamics Restrained by Nuclear Overhauser Effects

Feng, B.,Stone, M.P.
(1995)  Chem.Res.Toxicol.  8 : 821