Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
ALZ 2-[N'-(4-amino-butyl)-hydrazinocarbonyl]-pyrrolidine-1-carboxylic acid benzyl ester
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modified Residues
Code Name Link
TYS O-sulfo-L-tyrosine
Code : 1AFE   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : HUMAN ALPHA-THROMBIN INHIBITION BY CBZ-PRO-AZALYS-ONP
Release Data : 1997-12-03
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN (SMALL SUBUNIT) L
ec: 3.4.21.5
mol_id molecule chains
2 ALPHA-THROMBIN (LARGE SUBUNIT) H
ec: 3.4.21.5
mol_id molecule chains synonym
3 HIRUGEN I N-ACETYLHIRUDIN 53 - 64 WITH SULFATO-TYR 63
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
organ: BLOOD
tissue: PLASMA
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
organ: BLOOD
tissue: PLASMA
mol_id organism_scientific organism_common
3 Hirudo medicinalis  (taxid:6421) Medicinal leech
Authors : De Simone, G., Balliano, G., Milla, P., Gallina, C., Giordano, C., Tarricone, C., Rizzi, M., Bolognesi, M., Ascenzi, P.
Keywords : COMPLEX (SERINE PROTEASE-INHIBITOR), BLOOD COAGULATION, N-CARBOBENZOXY-PRO-ALFA-AZALYS-P-NITROPHENYLESTER, SERINE PROTEINASE INHIBITION, GLYCOSYLATED PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.

De Simone, G.,Balliano, G.,Milla, P.  et al.
(1997)  J.Mol.Biol.  269 : 558 - 569

PubMed: 9217260
DOI: 10.1006/jmbi.1997.1037

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction : Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Chain : I
UniProt : P28501 (HIRV1_HIRME)
Reaction : -