Het-PDB Navi2 (PDB: 1AE8)

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Ligands
Code	Name		Style	Show	Link
AZL	1-ethoxycarbonyl-D-phe-pro-2(4-aminobutyl)hydrazine				PoSSuM

Non-standard Residues
Code	Name	Show
TYS	O-sulfo-L-tyrosine

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 1AE8

Code :

1AE8 PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

HUMAN ALPHA-THROMBIN INHIBITION BY EOC-D-PHE-PRO-AZALYS-ONP

Release Data :

1997-12-03

Compound :

mol_id	molecule	chains
1	ALPHA-THROMBIN (SMALL SUBUNIT)	L
	ec: 3.4.21.5

mol_id	molecule	chains
2	ALPHA-THROMBIN (LARGE SUBUNIT)	H
	ec: 3.4.21.5

mol_id	molecule	chains	synonym
3	HIRUGEN	I	N-ACETYLHIRUDIN 53 - 64 WITH SULFATO-TYR 63

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	organ: BLOOD tissue: PLASMA

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	organ: BLOOD tissue: PLASMA

mol_id	organism_scientific	organism_common
3	Hirudo medicinalis (taxid:6421)	Medicinal leech

Authors :

De Simone, G., Balliano, G., Milla, P., Gallina, C., Giordano, C., Tarricone, C., Rizzi, M., Bolognesi, M., Ascenzi, P.

Keywords :

COMPLEX (SERINE PROTEASE-INHIBITOR), BLOOD COAGULATION, N-ETHOXYCARBONYL-D-PHE-PRO-ALFA-AZALYS-P-NITROPHENYLESTER, SERINE PROTEINASE INHIBITION, GLYCOSYLATED PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.

De Simone, G.,Balliano, G.,Milla, P. et al.
(1997) J.Mol.Biol. 269 : 558 - 569

PubMed: 9217260
DOI: 10.1006/jmbi.1997.1037

Chain :	I
UniProt :	P28501 (HIRV1_HIRME)
Reaction :	-

PDB ID: 1AE8

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