Brand  (β version)

PDB ID: 1AE4

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Ligands
Code Name Style Show Link
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
TOL Tolrestat PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1AE4   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : ALDEHYDE REDUCTASE COMPLEXED WITH COFACTOR AND INHIBITOR, ALPHA CARBON ATOMS ONLY
Release Data : 1998-03-11
Compound :
mol_id molecule chains synonym
1 ALDEHYDE REDUCTASE A ALR1
ec: 1.1.1.2
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
organ: KIDNEY
tissue: MEDULLA, CORTEX
Authors : El-Kabbani, O.
Keywords : ALDO-KETO REDUCTASE, OXIDOREDUCTASE, TIM-BARREL
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Studies on the inhibitor-binding site of porcine aldehyde reductase: crystal structure of the holoenzyme-inhibitor ternary complex.

el-Kabbani, O.,Carper, D.A.,McGowan, M.H.  et al.
(1997)  Proteins  29 : 186 - 192

PubMed: 9329083
DOI: 10.1002/(SICI)1097-0134(199710)29:2<186::AID-PROT6>3.0.CO;2-B

Structure of Porcine Aldehyde Reductase Holoenzyme

El-Kabbani, O.,Judge, K.,Ginell, S.L.  et al.
(1995)  Nat.Struct.Biol.  2 : 687

Reaction

Chain : A
UniProt : P50578 (AK1A1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH 1.1.1.2 PubMed:12732097
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glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH 1.1.1.372 PubMed:12732097
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glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH 1.1.1.372 PubMed:12732097
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L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH 1.1.1.19 UniProtKB:P51635
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L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH 1.1.1.20 UniProtKB:P51635
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allyl alcohol + NADP(+) = acrolein + H(+) + NADPH 1.1.1.54 UniProtKB:P51635
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hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH - UniProtKB:P51635
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3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH - UniProtKB:P51635
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(R)-mevalonate + NADP(+) = (R)-mevaldate + H(+) + NADPH - UniProtKB:P51635
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NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3- carbaldehyde - PubMed:12732097
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