Het-PDB Navi2 (PDB: 1AE1)

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Ligands
Code	Name		Style	Show	Link
NAP	Nadp nicotinamide-adenine-dinucleotide phosphate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1AE1

Code :

1AE1 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

TROPINONE REDUCTASE-I COMPLEX WITH NADP

Release Data :

1998-11-18

Compound :

mol_id	molecule	chains
1	TROPINONE REDUCTASE-I	A,B
	ec: 1.1.1.236

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Datura stramonium (taxid:4076)	Jimsonweed	Escherichia coli BL21(DE3) (taxid:469008)
	cell_line: BL21 organ: CULTURED ROOT expression_system_strain: BL21 (DE3) expression_system_vector_type: PLASMID expression_system_vector: PET21D expression_system_plasmid: PETTR1

Authors :

Nakajima, K., Yamashita, A., Akama, H., Nakatsu, T., Kato, H., Hashimoto, T., Oda, J., Yamada, Y.

Keywords :

OXIDOREDUCTASE, TROPANE ALKALOID BIOSYNTHESIS, REDUCTION OF TROPINONE TO TROPINE, SHORT-CHAIN DEHYDROGENASE

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Crystal structures of two tropinone reductases: different reaction stereospecificities in the same protein fold.

Nakajima, K.,Yamashita, A.,Akama, H. et al.
(1998) Proc.Natl.Acad.Sci.USA 95 : 4876 - 4881

Two Tropinone Reductases with Different Stereospecificities are Short-Chain Dehydrogenases Evolved from a Common Ancestor

Nakajima, K.,Hashimoto, T.,Yamada, Y.
(1993) Proc.Natl.Acad.Sci.USA 90 : 9591

Chain :

A, B

UniProt :

P50162 (TRN1_DATST)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
NADP(+) + tropine = H(+) + NADPH + tropinone	1.1.1.206	PubMed:8415746
NADP(+) + tropine = H(+) + NADPH + tropinone	-	PubMed:8415746

PDB ID: 1AE1