Brand  (β version)

PDB ID: 1AD4

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
HH2 6-hydroxymethylpterin-diphosphate PoSSuM
K Potassium ion PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1AD4   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : DIHYDROPTEROATE SYNTHETASE COMPLEXED WITH OH-CH2-PTERIN-PYROPHOSPHATE FROM STAPHYLOCOCCUS AUREUS
Release Data : 1998-04-29
Compound :
mol_id molecule chains synonym
1 DIHYDROPTEROATE SYNTHETASE A,B DHPS
ec: 2.5.1.15
Source :
mol_id organism_scientific
1 Staphylococcus aureus  (taxid:1280)
Authors : Oefner, C., Kostrewa, D.
Keywords : TRANSFERASE, SYNTHETASE, DIHYDROPTEROATE SYNTHETASE
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Structure and function of the dihydropteroate synthase from Staphylococcus aureus.

Hampele, I.C.,D'Arcy, A.,Dale, G.E.  et al.
(1997)  J.Mol.Biol.  268 : 21 - 30

PubMed: 9149138
DOI: 10.1006/jmbi.1997.0944

Reaction

Chain : A, B
UniProt : O05701 (DHPS_STAAU)
Reaction: EC: Evidence:
Physiological Direction:
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate 2.5.1.15 PubMed:9149138
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P0AC13
ECO:0000305 | PubMed:9149138
Magnesium is required for activity, even if it seems to interact primarily with the substrate.