Het-PDB Navi2 (PDB: 1AD3)

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Ligands
Code	Name		Style	Show	Link
NAD	Nicotinamide-adenine-dinucleotide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
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Modification
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Download interaction data: 1AD3

Code :

1AD3 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

CLASS 3 ALDEHYDE DEHYDROGENASE COMPLEX WITH NICOTINAMIDE-ADENINE-DINUCLEOTIDE

Release Data :

1997-07-07

Compound :

mol_id	molecule	chains	synonym
1	ALDEHYDE DEHYDROGENASE (CLASS 3)	A,B	ALDH
	ec: 1.2.1.5

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Norway rat	Escherichia coli (taxid:562)
	organ: LIVER expression_system_strain: BH101 expression_system_plasmid: PTA1DH

Authors :

Liu, Z.-J., Rose, J., Wang, B.C.

Keywords :

NADP, OXIDOREDUCTASE, AROMATIC ALDEHYDE

Exp. method :

X-RAY DIFFRACTION ( 2.6 Å )

Citation :

The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold.

Liu, Z.J.,Sun, Y.J.,Rose, J. et al.
(1997) Nat.Struct.Biol. 4 : 317 - 326

PubMed: 9095201
DOI: 10.1038/nsb0497-317

Crystal Structure of a Class 3 Aldehyde Dehydrogenase at 2.6 Angstroms Resolution

Liu, Z.-J.,Hempel, J.,Sun, J. et al.
(1997) Enzymology and Molecular Biology of Carbonyl Metabolism 6 (in: Adv.Exp. Med.Biol., V.414) : 1

Conserved Residues in the Aldehyde Dehydrogenase Family

Hempel, J.,Liu, Z.-J.,Perozich, J. et al.
(1997) Enzymology and Molecular Biology of Carbonyl Metabolism 6 (in: Adv.Exp. Med.Biol., V.414) : 9

Preliminary Crystallographic Analysis of Class 3 Rat Liver Aldehyde Dehydrogenase

Rose, J.P.,Hempel, J.,Kuo, I. et al.
(1990) Proteins 8 : 305

Chain :

A, B

UniProt :

P11883 (AL3A1_RAT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH	1.2.1.5	PubMed:2831537
an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH	-	PubMed:2831537
H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate	-	UniProtKB:P47739
H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate	-	UniProtKB:P47739

PDB ID: 1AD3

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